To evaluate clinical results in elderly and frail patients with bladder cancer treated with curative conformal irradiation alone.
The records of ambulatory frail elderly patients, age >80 years, Charlson Comorbidity Index (CCI) >5, with invasive bladder cancer, were retrospectively analyzed. The patients were irradiated with curative intent. Acute and late toxicities were evaluated.
A total of 27 ambulatory patients were treated. Median age was 84.5 years and a median CCI of 6.5 was recorded. Median delivered radiation dose was 64 Gy. All patients completed the planned treatment. Grade 1-2 gastrointestinal (GI) and genitourinary (GU) toxicities were observed in 55.5% of patients (15/27). At the last follow-up, no late G3+ toxicities have been observed, with G1-2 toxicities reported in 11.1% of patients (3/27). Higher values of CCI were associated with higher acute GU/GI toxicities; there was a correlation between CCI and acute GU toxicity (
Our results demonstrate safety and feasibility of curative radiation therapy in very elderly and frail patients with bladder cancer using 3D conformal radiation therapy.
Tumori 2015; 101(6): 609 - 613
Article Type: ORIGINAL RESEARCH ARTICLE
AuthorsAnna Santacaterina, Angelo Platania, Carmela Palazzolo, Corrado Spatola, Grazia Acquaviva, Manuela Crispi, Giuseppe Privitera, Nicola Settineri, Stefano Pergolizzi
- • Accepted on 16/04/2015
- • Available online on 15/05/2015
- • Published in print on 14/11/2015
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- Santacaterina, Anna [PubMed] [Google Scholar] 1, * Corresponding Author (firstname.lastname@example.org)
- Platania, Angelo [PubMed] [Google Scholar] 1
- Palazzolo, Carmela [PubMed] [Google Scholar] 1
- Spatola, Corrado [PubMed] [Google Scholar] 2
- Acquaviva, Grazia [PubMed] [Google Scholar] 1
- Crispi, Manuela [PubMed] [Google Scholar] 1
- Privitera, Giuseppe [PubMed] [Google Scholar] 2
- Settineri, Nicola [PubMed] [Google Scholar] 1
- Pergolizzi, Stefano [PubMed] [Google Scholar] 3
Azienda OORR, Papardo-Piemonte Messina, Messina - Italy
AOU “Vittorio Emanuele”, PO “Rodolico” Catania, Catania - Italy
Department of Biomedical Sciences and Morphologic and Functional Imaging, University of Messina, Messina - Italy