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Transformation to small cell lung cancer as an acquired resistance mechanism in EGFR-mutant lung adenocarcinoma: a case report of complete response to etoposide and cisplatin

Abstract

First-line epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) for patients with advanced non-small cell lung cancer who were selected on the basis of EGFR mutations have improved the progression-free survival with acceptable toxicity compared to standard chemotherapy. However, acquired resistance to EGFR-TKIs has been identified as an important clinical problem. Transformation to small cell lung cancer (SCLC) is a rare mechanism of resistance to EGFR-TKI therapy. We describe the case of a 61-year-old man who presented transformation from adenocarcinoma to SCLC as the manifestation of acquired resistance after EGFR-TKI treatment. He underwent chemotherapy with etoposide and cisplatin and achieved a complete response.

Tumori 2015; 101(3): e96 - e98

Article Type: CASE REPORT

DOI:10.5301/tj.5000276

Authors

Ki-Eun Hwang, Jae-Wan Jung, Su-Jin Oh, Mi-Jeong Park, Young-Jun Shon, Keum-Ha Choi, Eun-Taik Jeong, Hak-Ryul Kim

Article History

Disclosures

Financial support: This study was supported by a grant from Wonkwang University in 2012.
Conflict of interest: The authors have no conflicts of interest to disclose.

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Authors

Affiliations

  • Department of Internal Medicine, Institute of Wonkwang Medical Science, Wonkwang University School of Medicine, Iksan - Korea
  • Department of Radiology, Institute of Wonkwang Medical Science, Wonkwang University School of Medicine, Iksan - Korea
  • Department of Pathology, Institute of Wonkwang Medical Science, Wonkwang University School of Medicine, Iksan - Korea

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