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Topoisomerase II alpha and microtubuleassociated protein-tau as a predictive marker in axillary lymph node positive breast cancer

Abstract

Aims and background. The aims of this study were to investigate the correlation between topoisomerase II alpha (TOP2A), microtubule-associated protein-tau (MAPtau) and other prognostic factors in breast cancer and to evaluate the predictive value of TOP2A and MAP-tau in breast cancer patients who received anthracycline and taxane-containing adjuvant chemotherapy.
Methods and study design. Seventy patients with axillary lymph node positive breast cancer who underwent curative surgery between January 2000 and December 2005 were evaluated retrospectively. The levels of protein expression of TOP2A and MAPtau were assessed using immunohistochemistry.
Results. Among the 70 patients, 43 (61.4%) showed TOP2A overexpression and 30 (42.9%) showed MAP-tau positivity. TOP2A overexpression was associated with p53 positivity and high histological grade. MAP-tau positivity was associated with a lower positive lymph node ratio, lower proliferative activity, and hormone receptor positivity. Based on the TOP2A and MAP-tau expression, there was no significant difference in disease-free survival in the breast cancer patients who received anthracycline and taxane-containing adjuvant chemotherapy.
Conclusions. We conclude that immunohistochemical analysis of TOP2A and MAPtau protein expression may not predict the benefits of adjuvant anthracycline and taxane chemotherapy in axillary node positive breast cancer.

Tumori 2014; 100(1): 80 - 86

Article Type: ORIGINAL RESEARCH ARTICLE

DOI:10.1700/1430.15820

Authors

Hye Sung Won, Kyoung Eun Lee, Sun Hee Sung, Moon Young Choi, Jung Youn Jo, Eun Mi Nam, Yeung-Chul Mun, Chu-Myong Seong, Soon Nam Lee

Article History

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Authors

  • Won, Hye Sung [PubMed] [Google Scholar]
    Division of Medical Oncology, Department of Internal Medicine, Uijeongbu St Mary’s Hospital, The Catholic University of Korea, Gyeonggi-do, Korea
  • Lee, Kyoung Eun [PubMed] [Google Scholar]
    Division of Hematology-Oncology, Department of Internal Medicine, Ewha Medical Research Center, School of Medicine, Ewha Womans University, Seoul, Korea
  • Sung, Sun Hee [PubMed] [Google Scholar]
    Department of Pathology, Ewha Medical Research Center, School of Medicine, Ewha Womans University, Seoul, Korea
  • Choi, Moon Young [PubMed] [Google Scholar]
    Division of Hematology-Oncology, Department of Internal Medicine, Busan Paik Hospital, College of Medicine, Inje University, Pusan, Korea
  • Jo, Jung Youn [PubMed] [Google Scholar]
    Division of Hematology-Oncology, Department of Internal Medicine, Ewha Medical Research Center, School of Medicine, Ewha Womans University, Seoul, Korea
  • Nam, Eun Mi [PubMed] [Google Scholar]
    Division of Hematology-Oncology, Department of Internal Medicine, Ewha Medical Research Center, School of Medicine, Ewha Womans University, Seoul, Korea
  • Mun, Yeung-Chul [PubMed] [Google Scholar]
    Division of Hematology-Oncology, Department of Internal Medicine, Ewha Medical Research Center, School of Medicine, Ewha Womans University, Seoul, Korea
  • Seong, Chu-Myong [PubMed] [Google Scholar]
    Division of Hematology-Oncology, Department of Internal Medicine, Ewha Medical Research Center, School of Medicine, Ewha Womans University, Seoul, Korea
  • Lee, Soon Nam [PubMed] [Google Scholar]
    Division of Hematology-Oncology, Department of Internal Medicine, Ewha Medical Research Center, School of Medicine, Ewha Womans University, Seoul

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