Tivantinib, a new option for second-line treatment of advanced hepatocellular carcinoma? The experience of Italian centers


In the last decades the management of hepatocellular carcinoma (HCC) has undergone significant changes following the introduction of novel therapies such as sorafenib, which have improved patient survival. Nevertheless, HCC is still the third most common cause of cancer-related death worldwide. The evidence-based therapy for advanced HCC that is unsuitable for locoregional treatment is limited to sorafenib, with no second-line option available. This article focuses on the development of the MET inhibitor tivantinib in HCC as a promising treatment option for patients who failed sorafenib. A randomized, placebo-controlled phase II study showed activity of tivantinib in patients with high MET expression. Based on these results, the METIV-HCC phase III study in second-line treatment for MET-high patients was initiated to demonstrate the survival advantage of tivantinib compared to placebo.

Tumori 2015; 101(2): 139 - 143




Lorenza Rimassa, Armando Santoro, Bruno Daniele, Domenico Germano, Antonio Gasbarrini, Stefania Salvagni, Gianluca Masi, Giovanni Abbadessa, Maria Lamar, Terri Goldberg, Camillo Porta

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  • Medical Oncology and Hematology Unit, Humanitas Cancer Center, Humanitas Clinical and Research Center, Rozzano (Milan) - Italy
  • Dipartimento di Oncologia, A.O. G. Rummo, Benevento - Italy
  • Gastroenterology Department, Catholic University of Rome, Rome - Italy
  • UOC Oncologia Medica, Azienda Ospedaliero-Universitaria di Parma, Parma - Italy
  • Divisione di Oncologia Medica Universitaria, Azienda Ospedaliero Universitaria Pisana, Pisa - Italy
  • Clnical Development, Translational Medicine, ArQule, Inc, Woburn, MA - USA
  • Clinical Development, Daiichi Sankyo, Inc, Edison, NJ - USA
  • Medical Oncology, I.R.C.C.S. San Matteo University Hospital Foundation, Pavia - Italy

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