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The inhibition of Wnt/beta-catenin signaling pathway in human colon cancer cells by sulindac

Abstract

The aberrant activation of Wnt/β-catenin signaling plays important roles in the initial development of colon cancer. Sulindac is a commonly used non-steroidal anti-inflammatory drug. We demonstrated the effects of sulindac on growth inhibition, apoptosis induction, and Wnt/β-catenin signaling suppression in human colon cancer cells. Sulindac significantly inhibited proliferation of HT-29 colon cancer cells in a dose- and time-dependent manner. Sulindac was found to induce the apoptosis of HT-29 cells and inhibit the Wnt/β-catenin pathway. The inhibition was further confirmed by the decreased protein levels of β-catenin. The results indicate that sulindac may play a beneficial role in the comprehensive treatment of colon cancer.

Tumori 2014; 100(1): 97 - 101

Article Type: ORIGINAL RESEARCH ARTICLE

DOI:10.1700/1430.15823

Authors

Wei-Ping Tai, Pin-Jin Hu, Jing Wu, Xiang-Chun Lin

Article History

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Authors

  • Tai, Wei-Ping [PubMed] [Google Scholar]
    Department of Gastroenterology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China and Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China
  • Hu, Pin-Jin [PubMed] [Google Scholar]
    Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China
  • Wu, Jing [PubMed] [Google Scholar]
    Department of Gastroenterology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China
  • Lin, Xiang-Chun [PubMed] [Google Scholar]
    Department of Gastroenterology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China

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