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Surgical approach to primary tumors of the chest wall in children and adolescents: 30 years of mono-institutional experience

Abstract

Aims and background

Chest wall reconstruction after surgical resection for malignancies in children is a challenge for surgeons because of growth-related complications. The aim of this study is to analyze the surgical treatment and outcomes of 30 pediatric and adolescent patients treated at Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy, over a 30-year period.

Methods

Pediatric patients undergoing chest wall resection were retrospectively reviewed and selected for malignant primary tumor. Endpoints were survival, recurrences, and long-term results. We also reported the use of the innovative rib-like technique in 2 young patients.

Results

Twenty-one patients were male. Median age was 13.7 years. Eleven patients (37%) presented with a chest wall mass. Twenty-six (87%) had Ewing sarcoma family tumors. Twenty-eight (94%) received neoadjuvant chemotherapy after histologic diagnosis. One rib was resected in 13 cases; 2 or 3 contiguous ribs in 8 cases. No postoperative mortality was observed and the complication rate was 40%. Overall survival was 85.2% (95% confidence interval [CI] 65.2%-94.2%) at 5 and 10 years. Relapse occurred in 7 patients. The 5-year disease-free survival rate was 82% (95% CI 62%-92%).

Conclusions

Long-term survival is achievable for chest wall tumors in a high-volume referral center where a multimodal treatment should be set to reach the best result. As advances in medical treatment have increased survival, surgical techniques must ensure a lasting functional result. When refining the reconstruction techniques, such as the rib-like approach, it is necessary to expand the options of curative surgery for young patients.

Tumori 2016; 102(1): 89 - 95

Article Type: ORIGINAL RESEARCH ARTICLE

DOI:10.5301/tj.5000416

Authors

Lara Girelli, Roberto Luksch, Marta G. Podda, Cristina Meazza, Nadia Puma, Paolo Scanagatta, Emilia Pecori, Barbara Diletto, Carlotta Galeone, Maura Massimino, Ugo Pastorino

Article History

Disclosures

Financial support: None.
Conflict of interest: None.

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Authors

Affiliations

  • Thoracic Surgery Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan - Italy
  • Pediatric Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan - Italy
  • Department of Radiotherapy, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan - Italy
  • Department of Clinical Sciences and Community Health, University of Milan, Milan - Italy

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