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Secondary breast angiosarcoma and paclitaxel-dependent prolonged disease control: report of two cases and review of the literature

Abstract

Secondary breast angiosarcomas are a well-known entity generally characterized by a poor outcome, especially in patients with advanced disease. Among the drugs with demonstrated activity, taxane derivatives are one of the most effective histology-driven treatments against angiosarcomas. We report two cases of secondary breast angiosarcoma, both characterized by a very peculiar behavior towards paclitaxel. Both patients showed local recurrence of angiosarcoma after primary surgery, and they achieved complete remission following treatment with weekly paclitaxel. When a locoregional recurrence was observed as a result of a brief treatment interruption or a treatment delay, a new complete remission was rapidly achieved with the resumption of the drug, without evidence of any significant adverse effects.

Tumori 2015; 101(2): e60 - e63

Article Type: CASE REPORT

DOI:10.5301/tj.5000252

Authors

Donatella Gambini, Roberto Visintin, Elisa Locatelli, Claudia Bareggi, Barbara Galassi, Letterio Runza, Concetta Blundo, Irina Sosnovskikh, Maurizio Tomirotti

Article History

Disclosures

Financial support: No financial support was received for this submission.
Conflict of interest: The authors have no conflict of interest.

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Authors

Affiliations

  • UO Oncologia Medica, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan - Italy
  • UO Anatomia Patologica, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan - Italy
  • UOS Chirurgia Senologica, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan - Italy
  • UOS Radiologia Senologica, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan - Italy

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