Advertisement

Relationship of MDA plasma concentrations to long-term survival of breast cancer patients

Abstract

Aims and background. Malondialdehyde (MDA) is a product of polyunsaturated fatty acid oxidation. Changes in MDA concentrations have been found in patients with various types of cancer. The aim of this study was to analyze the relationship of MDA plasma concentrations to the long-term survival of patients with breast cancer.
Methods and study design.We conducted a retrospective study which included 106 patients at various disease stages (I – n = 2; II – n = 30; III – n = 51; IV – n = 23). Plasma MDA concentrations were measured at the time of diagnosis. Study participants were divided into groups according to age (>55 years vs ≥55 years), disease stage, and MDA concentration (>9 mmol/L vs ≥9 mmol/L). Survival rates between groups were compared using the Kaplan-Meier method.
Results. We found that higher MDA concentrations were associated with lower survival rates in stage I and II breast cancer. No significant association was found in patients with stage III and IV disease. Multivariate analysis showed that the MDA level was the only independent prognostic factor for patient survival in the total study group (hazard ratio 1.57, P = 0.03).
Conclusion. MDA can be used as a prognostic factor in early stages of breast cancer.

Tumori 2014; 100(3): 333 - 337

Article Type: ORIGINAL RESEARCH ARTICLE

DOI:10.1700/1578.17220

Authors

Janina Didziapetriene, Giedre Smailyte, Jaroslav Bublevic, Birute Kazbariene, Vytautas Kasiulevicius, Rimantas Stukas

Article History

This article is available as full text PDF.

  • If you are a Subscriber, please log in now.

  • Article price: Eur 36,00
  • You will be granted access to the article for 72 hours and you will be able to download any format (PDF or ePUB). The article will be available in your login area under "My PayPerView". You will need to register a new account (unless you already own an account with this journal), and you will be guided through our online shop. Online purchases are paid by Credit Card through PayPal.
  • If you are not a Subscriber you may:
  • Subscribe to this journal
  • Unlimited access to all our archives, 24 hour a day, every day of the week.

Authors

Article usage statistics

The blue line displays unique views in the time frame indicated.
The yellow line displays unique downloads.
Views and downloads are counted only once per session.

No supplementary material is available for this article.