Breast cancer survivors have a high risk of cardiac death as a consequence of heart irradiation during left breast tangential radiotherapy (RT). This study compares the cardiac dose delivered by standard 3D conformal tangential RT (CRT) to that delivered by prospective-gating RT (PGRT) or 5-field intensity-modulated RT (IMRT).
Patients with early left breast cancer, referred for adjuvant RT to our institution, were enrolled in this study. For each patient, 2 simulation computed tomography scans were acquired: the first during free breathing, and the second on prospective gating during deep inspiration breath-hold. The scans were monitored by the Varian RPM™ respiratory gating system. For each patient, 3 treatment plans were performed: a 3D-CRT and an IMRT plan, each based on the free-breathing scan, and a PGRT plan, based on the deep inspiration breath-hold scan. Dose-volume histograms were compared by means of the Friedman test.
The median mean heart dose was 3 Gy (range 0.9-7.3 Gy) in the CRT plans, 1.9 Gy (range 0.5-3.6 Gy) in the PGRT plans, and 4.5 Gy (range 1.1-10.5 Gy) in the IMRT plans (p = 0.001). The mean heart V25 was 1.2% (range 0%-9.7%), 0% (range 0%-2.0%), and 0.2% (range 0%-7.3%) for CRT, PGRT, and IMRT plans, respectively (p<0.001).
Prospective-gating RT to the left breast offered the best protection of heart and lung, as well as a lower irradiation of the contralateral breast, compared to CRT or IMRT.
Tumori 2016; 102(2): 184 - 189
Article Type: ORIGINAL RESEARCH ARTICLE
AuthorsGiuseppe R. D’Agostino, Barbara Diletto, Giovanna Mantini, Luigia Nardone, Gian Carlo Mattiucci, Francesco Catucci, Roberta Canna, Antonella Martino, Luigi Azario, Vincenzo Valentini
- • Accepted on 20/07/2015
- • Available online on 05/09/2015
- • Published in print on 18/04/2016
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- D’Agostino, Giuseppe R. [PubMed] [Google Scholar] 1
- Diletto, Barbara [PubMed] [Google Scholar] 1, * Corresponding Author (firstname.lastname@example.org)
- Mantini, Giovanna [PubMed] [Google Scholar] 1
- Nardone, Luigia [PubMed] [Google Scholar] 1
- Mattiucci, Gian Carlo [PubMed] [Google Scholar] 1
- Catucci, Francesco [PubMed] [Google Scholar] 1
- Canna, Roberta [PubMed] [Google Scholar] 1
- Martino, Antonella [PubMed] [Google Scholar] 1
- Azario, Luigi [PubMed] [Google Scholar] 2
- Valentini, Vincenzo [PubMed] [Google Scholar] 1
Department of Radiation Oncology, Catholic University of the Sacred Heart, Rome - Italy
Department of Physics, Catholic University of the Sacred Heart, Rome - Italy
Giuseppe R. D’Agostino and Barbara Diletto contributed equally to this work.