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Rapid tumor shrinkage with lapatinib plus capecitabine in a patient with massive liver involvement

Abstract

We present the case of a 58-year-old woman with breast cancer metastasizing to the liver after adjuvant chemotherapy. A liver biopsy confirmed metastatic lesions from breast cancer that were immunohistochemically positive for estrogen/progesterone receptors and HER2. After first-line treatment with trastuzumab and vinorelbine, the patient commenced therapy with capecitabine (1000 mg/m2 twice daily, days 1-14) and lapatinib (1250 mg/day). Three months after the administration of this combination therapy, the liver metastases had shrunk substantially. Lapatinib may have the potential to convert trastuzumab-refractory tumors to trastuzumab-sensitive tumors in HER2-positive breast cancer by upregulation of the cell surface expression of HER2. Further study will be needed to evaluate in the clinic the combination of lapatinib and an m-TOR inhibitor as a treatment approach in HER2 overexpressing breast cancer that shows a poor response to trastuzumab.

Tumori 2013; 99(6): e278 - e281

Article Type: CASE REPORT

DOI:10.1700/1390.15468

Authors

Francesco Giotta, Agnese Latorre, Antonio Cramarossa, Giovanni Simone, Carlo Florio, Stefano Oliva, Vito Lorusso

Article History

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Authors

  • Giotta, Francesco [PubMed] [Google Scholar]
    Medical Oncology Department, National Cancer Research Center Giovanni Paolo II, Bari, Italy
  • Latorre, Agnese [PubMed] [Google Scholar]
    Medical Oncology Department, National Cancer Research Center Giovanni Paolo II, Bari, Italy
  • Cramarossa, Antonio [PubMed] [Google Scholar]
    Radiology Unit, National Cancer Research Center Giovanni Paolo II, Bari, Italy
  • Simone, Giovanni [PubMed] [Google Scholar]
    Anatomy and Histopathology Service, National Cancer Research Center Giovanni Paolo II, Bari, Italy
  • Florio, Carlo [PubMed] [Google Scholar]
    Radiology Unit, National Cancer Research Center Giovanni Paolo II, Bari, Italy
  • Oliva, Stefano [PubMed] [Google Scholar]
    Cardiology Unit, National Cancer Research Center Giovanni Paolo II, Bari, Italy
  • Lorusso, Vito [PubMed] [Google Scholar]
    Medical Oncology Department, National Cancer Research Center Giovanni Paolo II, Bari, Italy

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