To demonstrate that radiotherapy (RT) is a valid alternative to surgery in men ≤70 years old with localized prostate cancer.
From 1988 to 2009, 214 patients with T1-2 N0 M0 prostate cancer were treated with RT. The effects of patient- and treatment-related risk factors on toxicity were investigated.
Median follow-up was 105 months (range 14.2-180). The 5-, 10-, and 15-year biochemical relapse-free survival for all 214 patients was 80%, 61.9%, and 57.5%, respectively. In bivariate analysis, age (≤65 vs 65-70 years) was not a significant factor for biochemical relapse, while radiation dose was (p = 0.05) in multivariate analysis. Cancer-specific survival rates at 5, 10, and 15 years were 98.4%, 93.2%, and 69.7%, respectively. Median overall survival (OS) was 167 months (95% confidence interval 147.3-186.7). The OS rates at 5, 10, and 15 years were 91.8%, 75.8%, and 42.5%, respectively. Acute genitourinary (GU) and gastrointestinal (GI) toxicities occurred in 105 (49%) and 98 patients (45.8%), respectively, with only 2 cases of grade III GI toxicity. Late GU and GI toxicities occurred in 17 (7.9%) and 20 (9.3%) patients, respectively, with 1 grade III GI toxicity and 2 grade III GU toxicities. Risk factors for late toxicity were age and RT dose and technique, which were unrelated to acute toxicity.
Age ≤70 years does not consistently confer a negative prognosis for localized prostate cancer. Radiotherapy appears to be a viable alternative to surgery, offering excellent long-term cancer control.
Tumori 2016; 102(2): 209 - 216
Article Type: ORIGINAL RESEARCH ARTICLE
AuthorsRita Bellavita, Melissa Scricciolo, Vittorio Bini, Fabio Arcidiacono, Giampaolo Montesi, Valentina Lancellotta, Claudio Zucchetti, Marco Lupattelli, Isabella Palumbo, Cynthia Aristei
- • Accepted on 27/07/2015
- • Published online on 26/09/2015
- • Available online on 26/09/2015
- • Published in print on 18/04/2016
This article is available as full text PDF.
- Bellavita, Rita [PubMed] [Google Scholar] 1, * Corresponding Author (firstname.lastname@example.org)
- Scricciolo, Melissa [PubMed] [Google Scholar] 2
- Bini, Vittorio [PubMed] [Google Scholar] 3
- Arcidiacono, Fabio [PubMed] [Google Scholar] 1
- Montesi, Giampaolo [PubMed] [Google Scholar] 1
- Lancellotta, Valentina [PubMed] [Google Scholar] 1
- Zucchetti, Claudio [PubMed] [Google Scholar] 4
- Lupattelli, Marco [PubMed] [Google Scholar] 1
- Palumbo, Isabella [PubMed] [Google Scholar] 1
- Aristei, Cynthia [PubMed] [Google Scholar] 1
Institute of Radiation Oncology, General Hospital and University of Perugia, Perugia - Italy
Department of Radiotherapy, Ospedali Riuniti Ancona, Ancona - Italy
Department of Medicine, Endocrine and Metabolic Sciences Section, University of Perugia, Perugia - Italy
Department of Medical Physics, General Hospital of Perugia, Perugia - Italy