Advertisement

Prognostic factors affecting survival in malignant pleural mesothelioma: analysis of 125 subjects

Abstract

Aim of the study. Determining the pre-treatment prognostic factors in malignant pleural mesothelioma is important in terms of estimating the course of the disease and selecting patients who are candidate for multimodal therapy. The aim of the study was to determine the prognostic factors affecting survival in patients with malignant pleural mesothelioma.
Study design. One hundred and twenty-five patients who had been diagnosed histologically as having malignant pleural mesothelioma over the past 5 years were evaluated retrospectively. Relationships of survival of the patients with their age, gender, exposure to asbestos, smoking history, platelet, hemoglobin, leukocyte (WBC) and serum LDH values, histology, performance score and stage of disease were examined.
Results. Advanced clinical stage, N2 nodal involvement and the presence of distant metastasis were found to be related to survival. Sarcomatous histology was found to be a poor prognostic factor independently of other factors.
Conclusions. We showed that histological subtype and stage of disease were the most important parameters in planning the treatment, especially in determining the patients who were candidate for multimodal treatment and in estimating the prognosis.

Tumori 2014; 100(1): 55 - 59

Article Type: ORIGINAL RESEARCH ARTICLE

DOI:10.1700/1430.15816

Authors

Berna Komurcuoglu, A Kadri Cirak, S Cenk Kirakli, Gulru Polat, Nur Yucel, Ozan Usluer, Onur Erer, Gunseli Balci, Mine Gayaf, Filiz Guldaval, Serir Aktogu, Salih Guclu, Ayse Ozsoz, Huseyin Halilcolar

Article History

This article is available as full text PDF.

  • If you are a Subscriber, please log in now.

  • Article price: Eur 36,00
  • You will be granted access to the article for 72 hours and you will be able to download any format (PDF or ePUB). The article will be available in your login area under "My PayPerView". You will need to register a new account (unless you already own an account with this journal), and you will be guided through our online shop. Online purchases are paid by Credit Card through PayPal.
  • If you are not a Subscriber you may:
  • Subscribe to this journal
  • Unlimited access to all our archives, 24 hour a day, every day of the week.

Authors

  • Komurcuoglu, Berna [PubMed] [Google Scholar]
    Resporatory Medicine, Mesothelioma Study Group of Izmir Dr Suat Seren, Respiratory Diseases and Thoracic Surgery Training and Research Hospital, Mavisehir-Izmir, Turkey
  • Cirak, A Kadri [PubMed] [Google Scholar]
    Resporatory Medicine, Mesothelioma Study Group of Izmir Dr Suat Seren, Respiratory Diseases and Thoracic Surgery Training and Research Hospital, Mavisehir-Izmir, Turkey
  • Kirakli, S Cenk [PubMed] [Google Scholar]
    Resporatory Medicine, Mesothelioma Study Group of Izmir Dr Suat Seren, Respiratory Diseases and Thoracic Surgery Training and Research Hospital, Mavisehir-Izmir, Turkey
  • Polat, Gulru [PubMed] [Google Scholar]
    Resporatory Medicine, Mesothelioma Study Group of Izmir Dr Suat Seren, Respiratory Diseases and Thoracic Surgery Training and Research Hospital, Mavisehir-Izmir, Turkey
  • Yucel, Nur [PubMed] [Google Scholar]
    Pathology Department, Mesothelioma Study Group of Izmir Dr Suat Seren, Respiratory Diseases and Thoracic Surgery Training and Research Hospital, Mavisehir-Izmir, Turkey
  • Usluer, Ozan [PubMed] [Google Scholar]
    Thoracic Surgery, Mesothelioma Study Group of Izmir Dr Suat Seren, Respiratory Diseases and Thoracic Surgery Training and Research Hospital, Mavisehir-Izmir, Turkey
  • Erer, Onur [PubMed] [Google Scholar]
    Resporatory Medicine, Mesothelioma Study Group of Izmir Dr Suat Seren, Respiratory Diseases and Thoracic Surgery Training and Research Hospital, Mavisehir-Izmir, Turkey
  • Balci, Gunseli [PubMed] [Google Scholar]
    Resporatory Medicine, Mesothelioma Study Group of Izmir Dr Suat Seren, Respiratory Diseases and Thoracic Surgery Training and Research Hospital, Mavisehir-Izmir, Turkey
  • Gayaf, Mine [PubMed] [Google Scholar]
    Resporatory Medicine, Mesothelioma Study Group of Izmir Dr Suat Seren, Respiratory Diseases and Thoracic Surgery Training and Research Hospital, Mavisehir-Izmir, Turkey
  • Guldaval, Filiz [PubMed] [Google Scholar]
    Resporatory Medicine, Mesothelioma Study Group of Izmir Dr Suat Seren, Respiratory Diseases and Thoracic Surgery Training and Research Hospital, Mavisehir-Izmir, Turkey
  • Aktogu, Serir [PubMed] [Google Scholar]
    Resporatory Medicine, Mesothelioma Study Group of Izmir Dr Suat Seren, Respiratory Diseases and Thoracic Surgery Training and Research Hospital, Mavisehir-Izmir, Turkey
  • Guclu, Salih [PubMed] [Google Scholar]
    Resporatory Medicine, Mesothelioma Study Group of Izmir Dr Suat Seren, Respiratory Diseases and Thoracic Surgery Training and Research Hospital, Mavisehir-Izmir, Turkey
  • Ozsoz, Ayse [PubMed] [Google Scholar]
    Resporatory Medicine, Mesothelioma Study Group of Izmir Dr Suat Seren, Respiratory Diseases and Thoracic Surgery Training and Research Hospital, Mavisehir-Izmir, Turkey
  • Halilcolar, Huseyin [PubMed] [Google Scholar]
    Resporatory Medicine, Mesothelioma Study Group of Izmir Dr Suat Seren, Respiratory Diseases and Thoracic Surgery Training and Research Hospital, Mavisehir-Izmir, Turkey

Article usage statistics

The blue line displays unique views in the time frame indicated.
The yellow line displays unique downloads.
Views and downloads are counted only once per session.

No supplementary material is available for this article.