Advertisement

Platinum doublets as first-line treatment for elderly patients with advanced non-small cell lung cancer

Abstract

Aims and background. More than 50% of patients with advanced non-small cell lung cancer are diagnosed in the elderly. Few prospective clinical data with cisplatin-based chemotherapy are available, and some authors have suggested that a non-platinum single agent should be the preferred form of cure in these patients. The aim of the study was to evaluate the efficacy and safety of first-line chemotherapy based on platinums (carboplatin or cisplatin) plus a third generation compound (vinorelbine or gemcitabine) in elderly patients with advanced non-small cell lung cancer in daily clinical practice.
Methods. A retrospective analysis of consecutive elderly (≥70 years of age) patients with advanced non-small cell lung cancer treated at our Medical Oncology Unit from February 2005 to September 2011 was performed.
Results. A total of 249 cycles of chemotherapy was administered to 62 patients (median age, 72 years; range, 70-81) presenting a median Charlson comorbidity index of 1 and a good ECOG PS (0-1, 52 patients; 2, 10 patients). The median number of cycles/patient was 4, and all 62 patients received a platinum-based doublet as first-line chemotherapy: 57 with carboplatin (92%) and 5 with cisplatin (8%). As best response to the treatment, 19 (31%) partial responses and 20 (32%) stable diseases were observed. Median overall survival was 9.8 months. Toxicity was mild; grade III-IV neutropenia was the most frequently observed side effect in 19 administered cycles (8%).
Conclusions. Advanced non-small cell lung cancer in elderly patients can be safely treated with a platinum-based doublet. Observed toxicity is manageable, and overall survival is in keeping with data from the literature.

Tumori 2013; 99(6): 650 - 655

Article Type: ORIGINAL RESEARCH ARTICLE

DOI:10.1700/1390.15451

Authors

Paolo Piacentini, Filippo Greco, Anna Mercanti, Anna Rita Trolese, Emilia Durante, Giacomo Moratello, Michele Tognetto, Lara Furini, Jacopo Giuliani, Andrea Bonetti

Article History

This article is available as full text PDF.

  • If you are a Subscriber, please log in now.

  • Article price: Eur 36,00
  • You will be granted access to the article for 72 hours and you will be able to download any format (PDF or ePUB). The article will be available in your login area under "My PayPerView". You will need to register a new account (unless you already own an account with this journal), and you will be guided through our online shop. Online purchases are paid by Credit Card through PayPal.
  • If you are not a Subscriber you may:
  • Subscribe to this journal
  • Unlimited access to all our archives, 24 hour a day, every day of the week.

Authors

  • Piacentini, Paolo [PubMed] [Google Scholar]
    Department of Medical Oncology, Mater Salutis Hospital, ASL 21 della Regione Veneto, Legnago (VR), Italy
  • Greco, Filippo [PubMed] [Google Scholar]
    Department of Medical Oncology, Mater Salutis Hospital, ASL 21 della Regione Veneto, Legnago (VR), Italy
  • Mercanti, Anna [PubMed] [Google Scholar]
    Department of Medical Oncology, Mater Salutis Hospital, ASL 21 della Regione Veneto, Legnago (VR), Italy
  • Trolese, Anna Rita [PubMed] [Google Scholar]
    Department of Medical Oncology, Mater Salutis Hospital, ASL 21 della Regione Veneto, Legnago (VR), Italy
  • Durante, Emilia [PubMed] [Google Scholar]
    Department of Medical Oncology, Mater Salutis Hospital, ASL 21 della Regione Veneto, Legnago (VR), Italy
  • Moratello, Giacomo [PubMed] [Google Scholar]
    Department of Medical Oncology, Mater Salutis Hospital, ASL 21 della Regione Veneto, Legnago (VR), Italy
  • Tognetto, Michele [PubMed] [Google Scholar]
    Department of Medical Oncology, Mater Salutis Hospital, ASL 21 della Regione Veneto, Legnago (VR), Italy
  • Furini, Lara [PubMed] [Google Scholar]
    Department of Medical Oncology, Mater Salutis Hospital, ASL 21 della Regione Veneto, Legnago (VR), Italy
  • Giuliani, Jacopo [PubMed] [Google Scholar]
    Department of Medical Oncology, Mater Salutis Hospital, ASL 21 della Regione Veneto, Legnago (VR), Italy
  • Bonetti, Andrea [PubMed] [Google Scholar]
    Department of Medical Oncology, Mater Salutis Hospital, ASL 21 della Regione Veneto, Legnago (VR), Italy

Article usage statistics

The blue line displays unique views in the time frame indicated.
The yellow line displays unique downloads.
Views and downloads are counted only once per session.

No supplementary material is available for this article.