Advertisement

Perioperative high-dose-rate interstitial brachytherapy boost for patients with early breast cancer

Abstract

Aims and background. To evaluate the clinical results of perioperative high-dose-rate interstitial brachytherapy boost treatment preceding whole breast external beam radiation therapy in patients with early breast cancer.
Methods and study design. From 2005-2010, 100 patients with early breast cancer who met the eligibility criteria were enrolled in the study. Brachytherapy implant was performed during the breast-conserving surgery procedure. The boost treatment was started on the 3rd postoperative day to deliver a dose of 15 Gy in 6 fractions over 3 days. Three weeks later, external beam radiation therapy to the whole breast was started for a prescription dose of 50 Gy. The study end points were local recurrence, acute toxicity and cosmetic outcome.
Results. Median age of the patients was 46 years, and median follow-up was 52 months. No patient developed a local recurrence but 5 patients developed distant metastases. The 5-year overall survival and disease-free survival were 86% and 77%, respectively. Eleven patients had acute toxicity; 4 wound complications and 7 grade III skin toxicity. Nine of the 11 patients had breast size of more than 1500 cc. Except for the breast volume (>1500 cc), there was no statistically significant correlation between any of the patient or dosimetry-related factors and acute toxicity. Good-excellent cosmesis was observed in 87% of patients.
Conclusions. Perioperative high-dose-rate interstitial brachytherapy boost followed by whole breast external beam radiation therapy provides excellent local control, acceptable acute toxicity and good-excellent breast cosmesis in patients with early breast cancer.

Tumori 2013; 99(5): 604 - 610

Article Type: ORIGINAL RESEARCH ARTICLE

DOI:10.1700/1377.15310

Authors

Daya Nand Sharma, SVS Deo, Goura Kisor Rath, Nootan Kumar Shukla, Sanjay Thulkar, Renu Madan, Pramod Kumar Julka

Article History

This article is available as full text PDF.

  • If you are a Subscriber, please log in now.

  • Article price: Eur 36,00
  • You will be granted access to the article for 72 hours and you will be able to download any format (PDF or ePUB). The article will be available in your login area under "My PayPerView". You will need to register a new account (unless you already own an account with this journal), and you will be guided through our online shop. Online purchases are paid by Credit Card through PayPal.
  • If you are not a Subscriber you may:
  • Subscribe to this journal
  • Unlimited access to all our archives, 24 hour a day, every day of the week.

Authors

  • Sharma, Daya Nand [PubMed] [Google Scholar]
    Department of Radiation Oncology All India Institute of Medical Sciences, New Delhi, India
  • Deo, SVS [PubMed] [Google Scholar]
    Surgical Oncology All India Institute of Medical Sciences, New Delhi, India
  • Rath, Goura Kisor [PubMed] [Google Scholar]
    Department of Radiation Oncology All India Institute of Medical Sciences, New Delhi, India
  • Shukla, Nootan Kumar [PubMed] [Google Scholar]
    Surgical Oncology All India Institute of Medical Sciences, New Delhi, India
  • Thulkar, Sanjay [PubMed] [Google Scholar]
    Radiodiagnosis, All India Institute of Medical Sciences, New Delhi, India
  • Madan, Renu [PubMed] [Google Scholar]
    Department of Radiation Oncology All India Institute of Medical Sciences, New Delhi, India
  • Julka, Pramod Kumar [PubMed] [Google Scholar]
    Department of Radiation Oncology All India Institute of Medical Sciences, New Delhi, India

Article usage statistics

The blue line displays unique views in the time frame indicated.
The yellow line displays unique downloads.
Views and downloads are counted only once per session.

No supplementary material is available for this article.