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Outcome of definitive and postoperative radiotherapy in patients with sinonasal squamous cell carcinomas

Abstract

Aims

To evaluate outcomes in patients with sinonasal squamous cell carcinoma (SCC) treated with definitive radiotherapy (DRT) and postoperative radiotherapy (PORT).

Methods

Between 1990 and 2013, 73 patients with sinonasal SCC were treated with radiotherapy. Fifty-two patients (71.2%) were treated with DRT and 21 (28.8%) were treated with PORT. The primary tumor sites were the maxillary sinus in 47 patients (64.4%), the nasal cavity in 18 (24.7%), the ethmoid sinus in 7 (9.6%), and the frontal sinus in 1 (1.4%). Four (5.4%), 11 (15.1%), 24 (32.9%), 17 (23.3%), and 17 (23.3%) patients had T1, T2, T3, T4a, and T4b tumors, respectively. N stage was N0, N1, N2a, N2b, N2c, and N3 in 60 (82.2%), 6 (8.2%), 2 (2.7%), 2 (2.7%), and 3 (4.1%) patients, respectively. The median follow-up period was 23 months (range 3-196).

Results

The 5-year local progression-free survival (LPFS), regional progression-free survival (RPFS), distant metastasis-free survival (DMFS), and overall survival (OS) in the DRT and PORT groups were 50.6%, 82.1%, 91.1%, and 84.4% and 85.7%, 72.1%, 76.1%, and 83.5%, respectively, without any statistically significant differences.

Conclusions

The LPFS, RPFS, DMFS, and OS were not significantly different between the DRT and PORT groups. Given the possibility of functional disability and cosmetic disfigurement with facial surgery, DRT might be considered as a surrogate to surgery followed by PORT for patients with locally advanced sinonasal SCC.

Tumori 2016; 102(4): 426 - 432

Article Type: ORIGINAL RESEARCH ARTICLE

DOI:10.5301/tj.5000431

Authors

Shin-Hyung Park, Jeong Eun Lee, Dongbin Ahn

Article History

Disclosures

Financial support: Kyungpook National University Research Fund, 2012.
Conflict of interest: None.

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Authors

Affiliations

  • Department of Radiation Oncology, Kyungpook National University Hospital, Daegu - Korea
  • Department of Otolaryngology-Head and Neck Surgery, Kyungpook National University Hospital, Daegu - Korea

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