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Non-metastatic Ewing’s sarcoma family of tumors of bone in adolescents and adults: prognostic factors and clinical outcome-single institution results

Abstract

Aims and background. There is limited data regarding outcomes of Ewing’s sarcoma family of tumors in adolescents and adults compared with the same tumors in childhood. The aim of the study was to analyze prognostic factors and treatment results in a cohort of adolescents and adults with non-metastatic skeletal Ewing’s sarcoma family of tumors.
Methods and study design. From 1992-2008, 90 adolescents and adults with Ewing’s sarcoma family of tumors of the bone were referred to our institution. Sixty-five (72%) non-metastatic patients with analyzable data and treated in our institution were retrospectively evaluated. All patients were treated with alternated chemotherapy regimens administered every 3 weeks. The local treatment modality was selected according to tumor and patient characteristics.
Results. The median age was 21 years (range, 13-50). Most patients (74%) were >17 years of age. Forty-six percent of the tumors were located in the extremities. Local therapy was surgery in 45 patients and radiotherapy alone in 19 patients. Twenty-one patients received preoperative and 13 patients postoperative radiotherapy. Median follow-up was 43 months (range, 7-167). The 5-year event-free and overall survival rates for all patients were 44% and 49%, respectively. On univariate survival analysis, event-free and overall survival were worse for patients >17 years of age, tumor size >8 cm in diameter, an axial location, positive surgical margins, and poor histopathological response (>90% necrosis). Age, tumor site and tumor size on event-free and overall survival remained significant on multivariate analysis.
Conclusions. We identified age, tumor size, and tumor site as independent prognostic factors, in accord with the Western literature. These patients require novel treatment modalities.

Tumori 2014; 100(4): 452 - 458

Article Type: ORIGINAL RESEARCH ARTICLE

DOI:10.1700/1636.17910

Authors

Didem Colpan Öksüz, Deniz Tural, Fazilet Öner Dincbas, Sergülen Dervisoglu, Hande Turna, Murat Hiz, Fatih Kantarci, Beyhan Ceylaner, Sedat Koca, Nil Molinas Mandel

Article History

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Authors

  • Öksüz, Didem Colpan [PubMed] [Google Scholar]
    Department of Radiation Oncology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey
  • Tural, Deniz [PubMed] [Google Scholar]
    Department of Medical Oncology, Akdeniz University, Antalya, Turkey
  • Dincbas, Fazilet Öner [PubMed] [Google Scholar]
    Department of Radiation Oncology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey
  • Dervisoglu, Sergülen [PubMed] [Google Scholar]
    Department of Pathology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey
  • Turna, Hande [PubMed] [Google Scholar]
    Department of Medical Oncology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey
  • Hiz, Murat [PubMed] [Google Scholar]
    Department of Orthopedic Surgery, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey
  • Kantarci, Fatih [PubMed] [Google Scholar]
    Department of Radiology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey
  • Ceylaner, Beyhan [PubMed] [Google Scholar]
    Department of Radiation Oncology, Dr Lütfi Kirdar Training and Research Hospital, Istanbul, Turkey
  • Koca, Sedat [PubMed] [Google Scholar]
    Department of Radiation Oncology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul (retired), Turkey
  • Mandel, Nil Molinas [PubMed] [Google Scholar]
    Department of Medical Oncology, VKV American Hospital, Istanbul, Turkey

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