Misregulation of the dependence receptor DCC and its upstream lincRNA, LOC100287225, in colorectal cancer


Abstract Background

Long non-coding RNAs (lncRNAs), a class of regulatory RNAs, play a major role in various cellular processes. Long intergenic non-coding RNAs (lincRNAs), a subclass of lncRNAs, are involved in the trans- and cis-regulation of gene expression. In the case of cis-regulation, by recruiting chromatin-modifying complexes, lincRNAs influence adjacent gene expression.


We used quantitative real-time reverse-transcription polymerase chain reaction (qRT-PCR) to evaluate the coexpression of LOC100287225, a lincRNA, and DCC, one of its adjacent genes that is often decreased in colorectal cancer, in pairs of tumor and adjacent tumor-free tissues of 30 colorectal cancer patients.


The qRT-PCR results revealed the misregulation of these genes during tumorigenesis. Their relative expression levels were significantly lower in tumor tissues than adjacent tumor-free tissues. However, the analysis found no significant correlation between reduced expression of these genes.


Our study demonstrated the concurrent misregulation of DCC and LOC100287225 in colorectal cancer.

Tumori 2017; 103(1): 40 - 43




Mina Kazemzadeh, Reza Safaralizadeh, Mohammad Ali HosseinPour feizi, Mohammad Hossein Somi, Behrooz Shokoohi

Article History


Financial support: None.
Conflict of interest: There is no conflict of interest.

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  • Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz - Iran
  • Liver and Gastroenterology Diseases Research Center, Tabriz University of Medical Sciences, Tabriz - Iran
  • Department of Pathology, Tabriz University of Medical Sciences, Tabriz - Iran

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