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Misregulation of the dependence receptor DCC and its upstream lincRNA, LOC100287225, in colorectal cancer

Abstract

Abstract Background

Long non-coding RNAs (lncRNAs), a class of regulatory RNAs, play a major role in various cellular processes. Long intergenic non-coding RNAs (lincRNAs), a subclass of lncRNAs, are involved in the trans- and cis-regulation of gene expression. In the case of cis-regulation, by recruiting chromatin-modifying complexes, lincRNAs influence adjacent gene expression.

Methods

We used quantitative real-time reverse-transcription polymerase chain reaction (qRT-PCR) to evaluate the coexpression of LOC100287225, a lincRNA, and DCC, one of its adjacent genes that is often decreased in colorectal cancer, in pairs of tumor and adjacent tumor-free tissues of 30 colorectal cancer patients.

Results

The qRT-PCR results revealed the misregulation of these genes during tumorigenesis. Their relative expression levels were significantly lower in tumor tissues than adjacent tumor-free tissues. However, the analysis found no significant correlation between reduced expression of these genes.

Conclusions

Our study demonstrated the concurrent misregulation of DCC and LOC100287225 in colorectal cancer.

Tumori 2017; 103(1): 40 - 43

Article Type: ORIGINAL RESEARCH ARTICLE

DOI:10.5301/tj.5000426

Authors

Mina Kazemzadeh, Reza Safaralizadeh, Mohammad Ali HosseinPour feizi, Mohammad Hossein Somi, Behrooz Shokoohi

Article History

Disclosures

Financial support: None.
Conflict of interest: There is no conflict of interest.

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Authors

Affiliations

  • Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz - Iran
  • Liver and Gastroenterology Diseases Research Center, Tabriz University of Medical Sciences, Tabriz - Iran
  • Department of Pathology, Tabriz University of Medical Sciences, Tabriz - Iran

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