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miRNA-214: expression, therapeutic and diagnostic potential in cancer

Abstract

MicroRNAs (miRNAs) are small noncoding RNAs that negatively regulate gene expression by binding to the 3’ untranslated region of their target mRNAs. Recent work supports a role for miRNAs in the initiation and progression of human cancer. miRNA-214 not only mediates differentiation, senescence, angiogenesis, cell migration and virus replication but also acts as a tumor suppressor gene and oncogene. Increasing evidence indicates that miRNA-214 may serve as a biomarker in some cancer types. The aim of this review is to highlight and clarify the complexity of miRNA-214 activity, emphasizing its significant therapeutic and diagnostic potential.

Tumori 2015; 101(4): 375 - 383

Article Type: ORIGINAL RESEARCH ARTICLE

DOI:10.5301/tj.5000318

Authors

Hengpeng He, Hao Zhang, Zhiguo Li, Rui Wang, Nuo Li, Li Zhu

Article History

Disclosures

Financial support: None.
conflicts of interest: The authors have no conflict of interest directly related to this study.

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Authors

Affiliations

  • Department of Laboratory, The Fourth Affiliated Hospital of China Medical University, Shenyang - China
  • Department of Pathology, The Fourth Affiliated Hospital of China Medical University, Shenyang - China
  • Department of Gastroenterology, The Fourth Affiliated Hospital of China Medical University, Shenyang - China
  • Department of Central Laboratory, School of Stomatology, China Medical University, Shenyang - China

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