Minimally invasive video-assisted thyroidectomy (MIVAT) was initially introduced for the treatment of selected patients who met certain thyroid volume, nodule size and pathological criteria. Recent studies indicate that the completeness of resection of malignant nodules is comparable to that obtained with conventional thyroidectomy.
To compare the 5-year outcomes in patients with papillary thyroid carcinoma (PTC) treated with MIVAT versus conventional thyroidectomy.
In this prospective cohort study conducted over 2 years (July 2005-June 2007), 172 patients with node-negative, nonmetastatic PTC underwent either MIVAT (n = 67) or conventional thyroidectomy (n = 105). Study outcomes were 1) the cumulative dose of radioactive iodine (RAI) to achieve a disease-free state, defined as a stimulated serum thyroglobulin (Tg) level <2 ng/mL with negative Tg antibody and no tumor on a whole-body scan or cross-sectional imaging, and 2) the 5-year serum Tg level.
The clinical parameters of the MIVAT and conventional thyroidectomy groups were comparable except for age (mean 43 ± 12 vs. 59 ± 17 years, respectively; p = 0.03) and operative time (mean 69 ± 24 vs. 53 ± 16 minutes, p = 0.02); the mean tumor size was similar between groups (1.3 ± 0.7 vs. 1.6 ± 0.9 cm, p = 0.14). Surgical morbidity was similar in both groups. Median follow-up was 5 years. RAI dose (mean 72 ± 38 vs. 96 ± 47 mCu, p = 0.34) and serum Tg at 5 years (mean 0.3 ± 0.2 vs. 0.5 ± 0.3 ng/mL, p = 0.30) were not significantly different between the MIVAT and conventional thyroidectomy groups.
MIVAT can be safely utilized in patients with localized PTC, providing comparable completeness of resection and oncological outcome to conventional thyroidectomy.
Tumori 2015; 101(2): 144 - 147
Article Type: ORIGINAL RESEARCH ARTICLE
AuthorsPaolo Del Rio, Umberto Maestroni, Mario Sianesi, Lorenzo Viani, Diego Vicente, Alexander Stojadinovic, Itzhak Avital
- • Accepted on 09/09/2014
- • Available online on 16/03/2015
- • Published in print on 28/04/2015
This article is available as full text PDF.
- Rio, Paolo Del [PubMed] [Google Scholar] 1, * Corresponding Author (email@example.com)
- Maestroni, Umberto [PubMed] [Google Scholar] 1
- Sianesi, Mario [PubMed] [Google Scholar] 1
- Viani, Lorenzo [PubMed] [Google Scholar] 1
- Vicente, Diego [PubMed] [Google Scholar] 2
- Stojadinovic, Alexander [PubMed] [Google Scholar] 2, 3, 4
- Avital, Itzhak [PubMed] [Google Scholar] 4, 5
Department of Surgery, University Hospital of Parma, Parma - Italy
Department of Surgery, Walter Reed National Military Medical Center, Bethesda, MD - USA
United States Military Cancer Institute, Bethesda, MD - USA
Uniformed Services University of the Health Sciences, Bethesda, MD - USA
Bon Secours Cancer Institute, Richmond, VA - USA