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Metastatic melanoma with spontaneous regression, psoriasis and HLA-Cw6: case report and a hypothesis to explore

Abstract

Spontaneous regressions of metastatic melanoma are rare, but several cases have been described in the literature. Although the mechanism of the phenomenon is not well understood, it is postulated that an activation of the immune system is behind it. Here we report the case of a patient with metastatic melanoma that, without any treatment, regressed spontaneously. The patient presented psoriasis (a disease of the skin related with autoimmunity) linked with HLA-Cw6. We review the literature and hypothesize with the possible relationship between psoriasis, HLA-Cw6 and the spontaneous regression.

Tumori 2014; 100(4): e144 - e147

Article Type: CASE REPORT

DOI:10.1700/1636.17932

Authors

Sara Pérez Ramírez, Verónica Parra, José Antonio Avilés Izquierdo, José Luis Vicario, Miguel Martín, Iván Márquez-Rodas

Article History

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Authors

  • Ramírez, Sara Pérez [PubMed] [Google Scholar]
    Servicio de Oncología Médica, Instituto de Investigación Sanitaria Gregorio Marañón, Universidad Complutense, Madrid, Spain
  • Parra, Verónica [PubMed] [Google Scholar]
    Servicio de Anatomía Patológica, Instituto de Investigación Sanitaria Gregorio Marañón, Universidad Complutense, Madrid, Spain
  • Izquierdo, José Antonio Avilés [PubMed] [Google Scholar]
    Servicio de Dermatología, Instituto de Investigación Sanitaria Gregorio Marañón, Universidad Complutense, Madrid, Spain
  • Vicario, José Luis [PubMed] [Google Scholar]
    Centro regional de transfusiones de la Comunidad de Madrid, Madrid, Spain
  • Martín, Miguel [PubMed] [Google Scholar]
    Servicio de Oncología Médica, Instituto de Investigación Sanitaria Gregorio Marañón, Universidad Complutense, Madrid, Spain
  • Márquez-Rodas, Iván [PubMed] [Google Scholar]
    Servicio de Oncología Médica, Instituto de Investigación Sanitaria Gregorio Marañón, Universidad Complutense, Madrid, Spain

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