Medical conditions, family history of cancer, and the risk of biliary tract cancers



Scanty data exist on the role of personal medical conditions, except for gallstones, and family history of cancer on the risk of biliary tract cancers (BTC).


We analyzed this issue using data from two Italian case-control studies, including 159 cases of BTC and 795 matched hospital controls. Odds ratios (ORs) of BTC and corresponding 95% confidence intervals (CIs) were estimated using multiple logistic regression models.


Gallstones were associated with a 2-fold excess risk of BTC (95% CI 1.24-3.45). No significant associations were observed with other conditions investigated, including diabetes (OR 1.15, 95% CI 0.63-2.11), hypertension (OR 0.65, 95% CI 0.39-1.11), hyperlipidemia (OR 0.61, 95% CI 0.31-1.21), allergy (OR 0.64, 95% CI 0.29-1.40), gastroduodenal ulcer (OR 0.52, 95% CI 0.24-1.12), hepatitis (OR 2.02, 95% CI 0.35-11.67), benign thyroid diseases (OR 1.16, 95% CI 0.56-2.40), hysterectomy (OR 1.19, 95% CI 0.53-2.68), unilateral oophorectomy (OR 1.75, 95% CI 0.44-6.93), and bilateral oophorectomy (OR 2.48, 95% CI 0.79-7.82). We found an excess risk of BTC in relation to family history of any cancer (OR 1.52, 95% CI 1.03-2.24) and family history of gallbladder cancer (OR 3.83, 95% CI 0.59-24.75).


The present study confirms a strong association between BTC and history of gallstones, and provides further evidence of a positive association with family history of cancer.

Tumori 2016; 102(3): 252 - 257




Valentina Rosato, Cristina Bosetti, Luigino Dal Maso, Maurizio Montella, Diego Serraino, Eva Negri, Carlo La Vecchia

Article History


Financial support: Supported by the Italian Foundation for Cancer Research (FIRC) and the Italian Association for Cancer Research (AIRC, grant number 13203).
Conflict of interest: None.

This article is available as full text PDF.

  • If you are a Subscriber, please log in now.

  • Article price: Eur 36,00
  • You will be granted access to the article for 72 hours and you will be able to download any format (PDF or ePUB). The article will be available in your login area under "My PayPerView". You will need to register a new account (unless you already own an account with this journal), and you will be guided through our online shop. Online purchases are paid by Credit Card through PayPal.
  • If you are not a Subscriber you may:
  • Subscribe to this journal
  • Unlimited access to all our archives, 24 hour a day, every day of the week.



  • Department of Epidemiology, Mario Negri Institute for Pharmacological Research, IRCCS, Milan - Italy
  • Unit of Epidemiology and Biostatistics, CRO Aviano National Cancer Institute IRCCS, Aviano (Pordenone) - Italy
  • Unit of Epidemiology, National Cancer Institute “G. Pascale Foundation”, Naples - Italy
  • Department of Clinical Sciences and Community Health, University of Milan, Milan - Italy

Article usage statistics

The blue line displays unique views in the time frame indicated.
The yellow line displays unique downloads.
Views and downloads are counted only once per session.

No supplementary material is available for this article.