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Medical conditions, family history of cancer, and the risk of biliary tract cancers

Abstract

Background

Scanty data exist on the role of personal medical conditions, except for gallstones, and family history of cancer on the risk of biliary tract cancers (BTC).

Methods

We analyzed this issue using data from two Italian case-control studies, including 159 cases of BTC and 795 matched hospital controls. Odds ratios (ORs) of BTC and corresponding 95% confidence intervals (CIs) were estimated using multiple logistic regression models.

Results

Gallstones were associated with a 2-fold excess risk of BTC (95% CI 1.24-3.45). No significant associations were observed with other conditions investigated, including diabetes (OR 1.15, 95% CI 0.63-2.11), hypertension (OR 0.65, 95% CI 0.39-1.11), hyperlipidemia (OR 0.61, 95% CI 0.31-1.21), allergy (OR 0.64, 95% CI 0.29-1.40), gastroduodenal ulcer (OR 0.52, 95% CI 0.24-1.12), hepatitis (OR 2.02, 95% CI 0.35-11.67), benign thyroid diseases (OR 1.16, 95% CI 0.56-2.40), hysterectomy (OR 1.19, 95% CI 0.53-2.68), unilateral oophorectomy (OR 1.75, 95% CI 0.44-6.93), and bilateral oophorectomy (OR 2.48, 95% CI 0.79-7.82). We found an excess risk of BTC in relation to family history of any cancer (OR 1.52, 95% CI 1.03-2.24) and family history of gallbladder cancer (OR 3.83, 95% CI 0.59-24.75).

Conclusions

The present study confirms a strong association between BTC and history of gallstones, and provides further evidence of a positive association with family history of cancer.

Tumori 2016; 102(3): 252 - 257

Article Type: ORIGINAL RESEARCH ARTICLE

DOI:10.5301/tj.5000397

Authors

Valentina Rosato, Cristina Bosetti, Luigino Dal Maso, Maurizio Montella, Diego Serraino, Eva Negri, Carlo La Vecchia

Article History

Disclosures

Financial support: Supported by the Italian Foundation for Cancer Research (FIRC) and the Italian Association for Cancer Research (AIRC, grant number 13203).
Conflict of interest: None.

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Authors

Affiliations

  • Department of Epidemiology, Mario Negri Institute for Pharmacological Research, IRCCS, Milan - Italy
  • Unit of Epidemiology and Biostatistics, CRO Aviano National Cancer Institute IRCCS, Aviano (Pordenone) - Italy
  • Unit of Epidemiology, National Cancer Institute “G. Pascale Foundation”, Naples - Italy
  • Department of Clinical Sciences and Community Health, University of Milan, Milan - Italy

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