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Management of patients with castration-resistant prostate cancer (CRPC): results of an Italian survey using the delphi method

Abstract

Purpose

To assess the opinions of urologists, oncologists and radiation oncologists on the indication for androgen deprivation therapy (ADT) and the definition and management of castration-resistant prostate cancer (CRPC).

Methods

In this study using the Delphi method, a list of 15 statements (66 items overall) addressing key issues in ADT and CRPC was sent to 255 participants (urologists, oncologists and radiation oncologists). Responses were rated on a 5-point Likert scale (1=strong disagreement; 5=strong agreement). Disagreement was defined as ≥66% responses with scores 1-2 and agreement as ≥66% responses with scores 3-5. No consensus was absence of agreement/disagreement.

Results

Overall, there was agreement and disagreement in 50% and 15% of the items, respectively. In 71.2% of the items the panelists agreed with each other. The highest concordance rate was observed between urologists and oncologists (87.8%). There were no items with 3 different opinions between the specialists. All panelists agreed on the definition of CRPC. Urologists and oncologists agreed on the recommendation to continue ADT in CRPC. In both nonmetastatic and metastatic asymptomatic CRPC patients with biochemical progression, treatment should be based on PSA kinetics. The panelists agreed on the use of chemotherapy in symptomatic and asymptomatic metastatic CRPC patients but not in those with nonmetastatic CRPC. There was agreement on the timing of initiation of abiraterone and enzalutamide either before or after chemotherapy.

Conclusions

With few exceptions there was agreement among urologists, oncologists and radiation oncologists about the management of CRPC, although the indications were not always in line with international guidelines.

Tumori 2016; 102(5): 514 - 520

Article Type: ORIGINAL RESEARCH ARTICLE

DOI:10.5301/tj.5000389

Authors

Carlo Terrone, Alfredo Berruti, Mauro Papotti, Vittorio Vavassori, Alessandro Sciarra

Article History

Disclosures

Financial support: None.
Conflict of interest: The authors have no competing interests to disclose.

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Authors

Affiliations

  • Division of Urology, Department of Translational Medicine, University of Eastern Piedmont, Novara - Italy
  • Medical Oncology Unit, University of Brescia at Spedali Civili Hospital, Brescia - Italy
  • Division of Pathology, Department of Oncology, University of Turin at San Luigi Hospital, Orbassano (Turin) - Italy
  • Division of Radiotherapy, Cliniche Gavazzeni-Humanitas, Bergamo - Italy
  • Prostate Cancer Unit, Department of Urology, Policlinico Umberto I, Sapienza University, Rome - Italy

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