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Lymphadenectomy in early stage endometrial cancer: a critical review of the current literature

Abstract

To date there has been no consensus on the exact oncological importance of systematic lymphadenectomy in early stage endometrial cancer. In this scenario, the balance between potential therapeutic benefit and procedure-related morbidity plays a central role in the indication for the procedure since the likelihood of detecting a metastatic node is relatively low. Compared with laparotomy, laparoscopic lymphadenectomy has several clearly demonstrated advantages and is an important tool to reduce morbidity. Additionally, many authors have developed less invasive methods to selectively identify patients who are at increased risk of lymph node involvement. This paper aims to review the current literature evidence and guidelines regarding the role of lymphadenectomy in patients with early stage endometrial cancer. Alternatives such as lymphatic sampling or sentinel lymph node biopsy are possible solutions but must be further investigated through more comprehensive studies.

Tumori 2014; 100(5): 477 - 485

Article Type: REVIEW

DOI:10.1700/1660.18154

Authors

Daniela Freitas dos Santos Siufi, João Siufi Neto, Mauricio Simões Abrão, Giovanni Favero

Article History

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Authors

  • Siufi, Daniela Freitas dos Santos [PubMed] [Google Scholar]
    Research fellow, Gynecology Department, Mayo Clinic Arizona, Phoenix, AZ, United States of America
  • Neto, João Siufi [PubMed] [Google Scholar]
    Research fellow, Gynecology Department, Mayo Clinic Arizona, Phoenix, AZ, United States of America
  • Abrão, Mauricio Simões [PubMed] [Google Scholar]
    Department of Obstetrics and Gynecology, University of São Paulo, São Paulo, SP, Brazil
  • Favero, Giovanni [PubMed] [Google Scholar]
    Department of Obstetrics and Gynecology, University of São Paulo, São Paulo, SP, Brazil

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