To investigate the expression of YAP protein by immunohistochemistry in prostate cancer tissues and hyperplasia or normal prostate tissues adjacent to cancer, and establish the correlation of YAP expression with Gleason score.
The expression of YAP protein was evaluated in tissue microarray by immunohistochemistry. The samples included 66 radical prostatectomy specimens with clinically detected prostate cancer and 54 hyperplasia or normal prostate tissues adjacent to cancer.
YAP expression was present mainly in the nuclei of basal cells in both prostate cancer tissues and normal prostate or hyperplasia tissues adjacent to cancer. Cytoplasmic expression of YAP was weaker than nuclear expression in both malignant and nonmalignant luminal epithelial cells. YAP expression was decreased or lost in prostate cancer tissues; hyperplasia or normal prostate tissues adjacent to cancer exhibited stronger nuclear and cytoplasmic expression of YAP (p = 0.0001). Downregulation of YAP expression in prostate cancer samples correlated with Gleason score increase (p = 0.002).
This immunohistochemical study expands our knowledge of the expression and localization of YAP in prostate cancer tissue and nonmalignant prostate tissue adjacent to cancer. YAP might function as a tumor suppressor in prostate cancer. Such information may provide the foundation for the treatment of preneoplastic and neoplastic lesions of the prostate.
Tumori 2015; 101(2): 189 - 193
Article Type: ORIGINAL RESEARCH ARTICLE
AuthorsXiaoyong Hu, Yingying Jia, Jianjun Yu, Jie Chen, Qiang Fu
- • Accepted on 03/12/2014
- • Available online on 17/04/2015
- • Published in print on 28/04/2015
This article is available as full text PDF.
- Hu, Xiaoyong [PubMed] [Google Scholar] 1, * Corresponding Author (firstname.lastname@example.org.)
- Jia, Yingying [PubMed] [Google Scholar] 2
- Yu, Jianjun [PubMed] [Google Scholar] 1
- Chen, Jie [PubMed] [Google Scholar] 3
- Fu, Qiang [PubMed] [Google Scholar] 1
Department of Urology, Shanghai Jiaotong University Affiliated Sixth People’s Hospital, Shanghai - China
State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai - China
Department of Pathology, Shanghai Jiaotong University Affiliated Sixth People’s Hospital, Shanghai Jiaotong University, Shanghai - China
Xiaoyong Hu and Yingying Jia contributed equally to the work