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Loss of YAP protein in prostate cancer is associated with Gleason score increase

Abstract

Aims and Background

To investigate the expression of YAP protein by immunohistochemistry in prostate cancer tissues and hyperplasia or normal prostate tissues adjacent to cancer, and establish the correlation of YAP expression with Gleason score.

Methods and Study design

The expression of YAP protein was evaluated in tissue microarray by immunohistochemistry. The samples included 66 radical prostatectomy specimens with clinically detected prostate cancer and 54 hyperplasia or normal prostate tissues adjacent to cancer.

Results

YAP expression was present mainly in the nuclei of basal cells in both prostate cancer tissues and normal prostate or hyperplasia tissues adjacent to cancer. Cytoplasmic expression of YAP was weaker than nuclear expression in both malignant and nonmalignant luminal epithelial cells. YAP expression was decreased or lost in prostate cancer tissues; hyperplasia or normal prostate tissues adjacent to cancer exhibited stronger nuclear and cytoplasmic expression of YAP (p = 0.0001). Downregulation of YAP expression in prostate cancer samples correlated with Gleason score increase (p = 0.002).

Conclusions

This immunohistochemical study expands our knowledge of the expression and localization of YAP in prostate cancer tissue and nonmalignant prostate tissue adjacent to cancer. YAP might function as a tumor suppressor in prostate cancer. Such information may provide the foundation for the treatment of preneoplastic and neoplastic lesions of the prostate.

Tumori 2015; 101(2): 189 - 193

Article Type: ORIGINAL RESEARCH ARTICLE

DOI:10.5301/tj.5000238

Authors

Xiaoyong Hu, Yingying Jia, Jianjun Yu, Jie Chen, Qiang Fu

Article History

Disclosures

Financial support: This work has been supported by the National Natural Science Foundation of China (30801150) and the ­Med-Tech Crossdisciplinary Foundation of Shanghai Jiaotong University (YG2012MS55).
Conflict of interest: All authors of the article “Loss of YAP protein in prostate cancer is associated with Gleason score increase” have no conflict of interest.

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Authors

Affiliations

  • Department of Urology, Shanghai Jiaotong University Affiliated Sixth People’s Hospital, Shanghai - China
  • State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai - China
  • Department of Pathology, Shanghai Jiaotong University Affiliated Sixth People’s Hospital, Shanghai Jiaotong University, Shanghai - China
  • Xiaoyong Hu and Yingying Jia contributed equally to the work

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