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Long-term outcome of high-risk prostate cancer treated with brachytherapy combined with external-beam radiation therapy and androgen deprivation therapy

Abstract

Aims and background. To evaluate long-term outcome and biochemical progressionfree survival (bPFS) in high-risk prostate cancer patients treated with brachytherapy combined with external-beam radiation therapy (EBRT) and androgen deprivation therapy (ADT).
Methods and study design.We retrospectively analyzed 97 high-risk prostate cancer patients treated with brachytherapy combined with EBRT and ADT. During follow-up, the post-operation prostate-specific antigen (PSA) level was monitored regularly and biochemical relapse, progression to castration-resistant prostate cancer or metastases, and causes of death were documented. We evaluated bPFS, cause-specific survival (CSS) and overall survival (OS).
Results. The bPFS, CSS and OS of the patients were 81.4%, 88.7% and 81.4%, respectively. The bPFS of the subcategories of patients stratified based on the presence or absence of a Gleason pattern 5 were 55.6% and 87.7%, respectively.
Conclusion. Brachytherapy combined with EBRT and ADT can effectively control PSA level and delay biochemical relapse in localized high-risk prostate cancer. However, patients presenting with a Gleason pattern 5 should be managed with further treatment intensification.

Tumori 2014; 100(5): 524 - 528

Article Type: ORIGINAL RESEARCH ARTICLE

DOI:10.1700/1660.18170

Authors

Jian Chen, Wei-gang Yan, Han-zhong Li, Zhi-gang Ji, Yi Zhou, Zhi-en Zhou, Zhi-peng Mai

Article History

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Authors

  • Chen, Jian [PubMed] [Google Scholar]
    Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
  • Yan, Wei-gang [PubMed] [Google Scholar]
    Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
  • Li, Han-zhong [PubMed] [Google Scholar]
    Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
  • Ji, Zhi-gang [PubMed] [Google Scholar]
    Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
  • Zhou, Yi [PubMed] [Google Scholar]
    Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
  • Zhou, Zhi-en [PubMed] [Google Scholar]
    Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
  • Mai, Zhi-peng [PubMed] [Google Scholar]
    Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China

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