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Long-lasting response with metronomic capecitabine in advanced hepatocellular carcinoma

Abstract

Effective and safe systemic treatment for advanced hepatocellular carcinoma (HCC) with severe underlying cirrhosis is not yet available. Sorafenib, an oral multikinase inhibitor, has proved to be effective in the treatment of patients affected by HCC with Child-Pugh class A liver function. For patients with cirrhosis-associated HCC having Child-Pugh class B and C liver function, no systemic treatments of documented efficacy and safety exist.We report a case of metastatic HCC associated with Child-Pugh class B cirrhosis that was treated with low, “metronomic” doses of capecitabine (1000 mg/day continuously). This treatment was effective and well tolerated and the response was maintained for 18 months. Metronomic capecitabine may represent a possible alternative in the treatment of those patients with advanced cirrhosis-associated HCC who cannot be treated with sorafenib. Free full text available at www.tumorionline.it

Tumori 2010; 96(5): 768 - 770

Article Type: CASE REPORT

Authors

Pierluigi Ballardini, Ivan Marri, Guido Margutti, Camillo Aliberti, Giorgio Benea, Roberto Manfredini

Article History

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Authors

  • Ballardini, Pierluigi [PubMed] [Google Scholar]
    Department of Internal Medicine, Ospedale del Delta, Lagosanto (FE) - Azienda USL of Ferrara, Italy
  • Marri, Ivan [PubMed] [Google Scholar]
    Department of Radiology, Ospedale del Delta, Lagosanto (FE) - Azienda USL of Ferrara, Italy
  • Margutti, Guido [PubMed] [Google Scholar]
    Department of Internal Medicine, Ospedale del Delta, Lagosanto (FE) - Azienda USL of Ferrara, Italy
  • Aliberti, Camillo [PubMed] [Google Scholar]
    Department of Radiology, Ospedale del Delta, Lagosanto (FE) - Azienda USL of Ferrara, Italy
  • Benea, Giorgio [PubMed] [Google Scholar]
    Department of Radiology, Ospedale del Delta, Lagosanto (FE) - Azienda USL of Ferrara, Italy
  • Manfredini, Roberto [PubMed] [Google Scholar]
    Department of Internal Medicine, Ospedale del Delta, Lagosanto (FE) - Azienda USL of Ferrara, Italy

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