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Lapatinib and platinum-based chemotherapy ameliorate breast cancer with choroidal metastasis and restore visual acuity

Abstract

Involvement of the central nervous system in metastatic breast cancer is a particularly dismal occurrence because of its effects on mortality and quality of life. Development of choroidal metastasis in a breast cancer patient indicates poor prognosis and has become the major life-limiting problem. Various treatment modalities for choroidal metastasis have been applied with different efficacy. Here we describe a patient with HER2-overexpressing breast cancer and limited choroidal metastasis who responded to an HER2 tyrosine kinase inhibitor after failure of radiotherapy and chemotherapy. Her visual acuity was completely and durably restored after the targeted therapy. This case provides a unique treatment experience of breast cancer with choroidal metastasis.

Tumori 2014; 100(3): e67 - e69

Article Type: CASE REPORT

DOI:10.1700/1578.17232

Authors

Uei-Han Ju, Ming-Ling Tsai, Chun-Shu Lin, Tsu-Yi Chao, Ming-Shen Dai

Article History

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Authors

  • Ju, Uei-Han [PubMed] [Google Scholar]
    Division of Hematology/Oncology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan
  • Tsai, Ming-Ling [PubMed] [Google Scholar]
    Department of Ophthalmology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan
  • Lin, Chun-Shu [PubMed] [Google Scholar]
    Department of Radiation Oncology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan
  • Chao, Tsu-Yi [PubMed] [Google Scholar]
    Division of Hematology/Oncology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan
  • Dai, Ming-Shen [PubMed] [Google Scholar]
    Division of Hematology/Oncology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan

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