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Increased expression of EphA2 and E-N cadherin switch in primary hepatocellular carcinoma

Abstract

Aim. To investigate the expression and clinical significance of ephrin type-A receptor 2 and epithelial-mesenchymal transition-related proteins in primary hepatocellular carcinoma.
Methods. Tissues from 52 primary hepatocellular carcinomas and 12 human normal liver tissues were detected for expression of ephrin type-A receptor 2, E-cadherin, and N-cadherin by immunochemistry. Cinicopathological features of hepatocellular carcinoma and tumor recurrence after operation were studied for the association with these molecular expressions and E-N cadherin switch.
Results. Increased expressions of ephrin type-A receptor 2 and N-cadherin and reduced expression of E-cadherin were significantly detected in hepatocellular carcinoma compared with normal liver tissues. Univariate analysis showed that there were close associations between unfavorable clinicopathological features and expressions of ephrin type-A receptor 2, E-cadherin, N-cadherin, and E-N cadherin switch. Ephrin type-A receptor 2 and E-cadherin expressions were confirmed as independent prognostic factors when corrected with age, gender, AFP, HBsAg, liver cirrhosis, tumor size, nodules, capsule, portal vein invasion, cell differentiation, and TNM stage.
Conclusions. The overexpression of ephrin type-A receptor 2 protein is correlated with the number of tumors, capsular integrity, portal vein cancer thrombus and clinical stages. Epithelial-mesenchymal transition regulated by ephrin type-A receptor 2 is involved in the aggressive clinicopathological features and prognosis, suggesting that the receptor may play an important role in the progression and metastasis of hepatocellular carcinoma.

Tumori 2013; 99(6): 689 - 696

Article Type: ORIGINAL RESEARCH ARTICLE

DOI:10.1700/1390.15457

Authors

Min Fan, Yu Liu, Fada Xia, Zhuolu Wang, Yun Huang, Jingdong Li, Zhiming Wang, Xinying Li

Article History

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Authors

  • Fan, Min [PubMed] [Google Scholar]
    Department of General Surgery, Xiangya Hospital, Central South University, Changsha, China
  • Liu, Yu [PubMed] [Google Scholar]
    Department of General Surgery, Xiangya Hospital, Central South University, Changsha, China
  • Xia, Fada [PubMed] [Google Scholar]
    Department of General Surgery, Xiangya Hospital, Central South University, Changsha, China
  • Wang, Zhuolu [PubMed] [Google Scholar]
    Department of General Surgery, Xiangya Hospital, Central South University, Changsha, China
  • Huang, Yun [PubMed] [Google Scholar]
    Department of General Surgery, Xiangya Hospital, Central South University, Changsha, China
  • Li, Jingdong [PubMed] [Google Scholar]
    Department of General Surgery, Xiangya Hospital, Central South University, Changsha, China
  • Wang, Zhiming [PubMed] [Google Scholar]
    Department of General Surgery, Xiangya Hospital, Central South University, Changsha, China
  • Li, Xinying [PubMed] [Google Scholar]
    Department of General Surgery, Xiangya Hospital, Central South University, Changsha, China

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