To explore the association of c-erbB-2 protein expression with clinicopathological characteristics and prognosis of gastric cancer (GC) after surgery.
A total of 133 patients undergoing surgical resection for GC between March 2006 and January 2009 in the Second Affiliated Hospital of Wenzhou Medical University were included in this study. c-erbB-2 protein expression was determined by immunohistochemistry. Afterwards, a meta-analysis was performed to further confirm the association between c-erbB-2 protein expression and GC by employing stringent inclusion and exclusion criteria. All data analyses were conducted with STATA 12.0 and SPSS 19.0.
There was no significant difference in c-erbB-2 expression among patients with various parameters including age, gender and histological types (all p>0.05). Among 133 GC patients, 32 patients presented c-erbB-2-positive expression and 101 presented c-erbB-2-negative expression (24.1% vs. 75.9%). The c-erbB-2-positive expression rate was significantly higher in GC tissues of patients with lymph node metastasis than those without. Similarly, a significant increase in c-erbB-2 expression was observed in well/moderately differentiated GC tissues compared with poorly differentiated GC. Patients with negative c-erbB-2 expression had a higher 5-year survival rate than those with positive c-erbB-2 expression, which was consistent with the results of the meta-analysis (OR = 0.54, 95% CI 0.37-0.80, p = 0.002).
Our study demonstrated that high expression of c-erbB-2 protein was strongly associated with lymph node metastasis, histological differentiation and 5-year survival rate in GC patients after surgery.
Tumori 2017; 103(3): 249 - 254
Article Type: ORIGINAL RESEARCH ARTICLE
AuthorsHao Wu, Zhenzhai Cai, Guangrong Lu, Shuguang Cao, He Huang, Yi Jiang, Weijian Sun
- • Accepted on 17/09/2015
- • Available online on 07/11/2015
- • Published in print on 12/05/2017
This article is available as full text PDF.
- Wu, Hao [PubMed] [Google Scholar]
- Cai, Zhenzhai [PubMed] [Google Scholar]
- Lu, Guangrong [PubMed] [Google Scholar]
- Cao, Shuguang [PubMed] [Google Scholar]
- Huang, He [PubMed] [Google Scholar]
- Jiang, Yi [PubMed] [Google Scholar]
- Sun, Weijian [PubMed] [Google Scholar] , * Corresponding Author (firstname.lastname@example.org)
Department of Gastroenterology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou - P.R. China