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Immunological status of chronic myelogenous leukemia patients with complete cytogenetic response after treatment

Abstract

Background

The aim of this study was to compare the T lymphocyte subsets of chronic myelogenous leukemia (CML) patients who had a complete cytogenetic response (CCyR) after treatment with imatinib (IM) or homoharringtonine (HHT).

Methods

T and Th lymphocyte subsets in CCyR patients treated with HHT (n = 15) or IM (n = 16) were assayed with flow cytometry.

Results

It was found that there were no differences in T lymphocyte subset proportions at the time of achieving CCyR0 and also no difference in the CD8+T cell proportions at the 12th month after CCyR (CCyR12), between the 2 groups. The values of CD3+T, CD4+T, CD8+T, CD4+T/CD8+T, Th1 and Th2 cells were 54.21% ± 6.12% vs. 44.32% ± 4.85%, 29.83% ± 5.53% vs. 22.27% ± 3.22%, 24.66 ± 4.91 vs. 25.41% ± 5.72% , 1.11 ± 0.23 vs. 0.92 ± 0.19, 10.23% ± 4.24% vs. 8.34% ± 3.45% and 11.12% ± 3.91% vs. 13.67% ± 4.78%, respectively in the HHT group and IM group at CCyR12, which meant that the proportions of CD3+T, CD4+T and Th1 cells and the ratio of CD4+T to CD8+T cells were higher and the CD8+T and Th2 cell proportions were lower in the HHT group than in the IM group.

Conclusions

HHT has a weaker immunodepression effect on T lymphocyte subsets compared with IM.

Tumori 2015; 101(3): 323 - 327

Article Type: ORIGINAL RESEARCH ARTICLE

DOI:10.5301/tj.5000287

Authors

Zhikui Deng, Yuanyuan Li, Yu-feng Li

Article History

Disclosures

Informed consent: This trial was approved by the Hospital Medical Research Ethics Committee.
Financial support: None.
Conflict of interest: None declared.

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Authors

Affiliations

  • Hematology Department, Huai’an First People’s Hospital, Nanjing Medical University, Huaian, Jiangsu - PR China

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