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Hepatosplenic T-cell lymphoma with aberrant expression of serum β-HCG: a case report

Abstract

Background

Peripheral T-cell lymphomas (PTCL) represent a heterogeneous group of hematologic malignancies frequently presenting at advanced stage of diagnosis.

Methods

We report a case of PTCL with an uncommon and aggressive onset with disseminated intravascular coagulation (DIC).

Results

Laboratory findings revealed an aberrant expression of β subunit of human chorionic gonadotropin (β-HCG). Other than for determination of pregnancy, β-HCG is regularly found as a tumor marker in germ cell tumors with trophoblastic differentiation and its aberrant expression has been reported in the literature in other neoplastic conditions only in the context of case reports.

Conclusions

In hematologic malignancies, β-HCG expression has been described only in sporadic cases. Awareness of this feature could avoid diagnostic delay in such an aggressive disease.

Tumori 2015; 101(6): e160 - e162

Article Type: CASE REPORT

DOI:10.5301/tj.5000373

Authors

Andrea Bellodi, Giulia Rivoli, Eleonora Arboscello, Giuseppe Fornarini, Giulio Fraternali Orcioni, Daniele Avenoso, Maurizio Miglino, Riccardo Ghio

Article History

Disclosures

Financial support: None.
Conflict of interest: None.

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Authors

Affiliations

  • Clinic of Internal Medicine 3, Department of Internal Medicine, Istituto di Ricerca a Carattere Clinico e Scientifico (IRCCS), Azienda Ospedaliera Universitaria (AOU) San Martino, Istituto Nazionale Tumori (IST), Genoa - Italy
  • Clinic of Hematology, Department of Internal Medicine, Istituto di Ricerca a Carattere Clinico e Scientifico (IRCCS), Azienda Ospedaliera Universitaria (AOU) San Martino, Istituto Nazionale Tumori (IST), Genoa - Italy
  • Medical Oncology, Department of Internal Medicine, Istituto di Ricerca a Carattere Clinico e Scientifico (IRCCS), Azienda Ospedaliera Universitaria (AOU) San Martino, Istituto Nazionale Tumori (IST), Genoa - Italy
  • Pathology Unit, Istituto di Ricerca a Carattere Clinico e Scientifico (IRCCS), Azienda Ospedaliera Universitaria (AOU) San Martino, Istituto Nazionale Tumori (IST), Genoa - Italy

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