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Timing should no longer be an obstacle to oocyte cryopreservation in patients with cancer

Timing should no longer be an obstacle to oocyte cryopreservation in patients with cancer

Tumori 2017; 103(2): 182 - 186

Article Type: ORIGINAL RESEARCH ARTICLE

DOI:10.5301/tj.5000586

Authors

Giorgia Mangili, Enrico Papaleo, Cristina Sigismondi, Rossella Masciangelo, Veronica Sarais, Veronica Giorgione, Roberta Nale, Laura Privitera, Letizia Carnelli, Valentina Di Mattei, Massimo Candiani

Abstract

Purpose

Anticancer treatment-related infertility is preventable with oocyte cryopreservation, but this is often not considered a relevant issue, due to lack of knowledge and time. The aim of this study is to prove that adequate organization of an Oncofertility Unit and the use of new protocols for controlled ovarian stimulation (COS) can reduce the time required by the procedure, encouraging consultants and patients to preserve fertility before gonadotoxic treatments.

Methods

A total of 125 patients diagnosed with malignant tumors were referred to the Oncofertility Unit of San Raffaele Hospital: 52 patients between April 2011 and October 2013 and 73 patients between October 2013 and November 2015. The 2 periods differ in office organization and type of COS protocol used.

Results

Between the 2 periods, a reduction in the mean number of days required from first counseling to the initiation (6.45 ± 1.058 vs 1.61 ± 0.228) and the end of the COS (17.83 ± 1.227 vs 13.70 ± 0.393) was observed (p<0.0001). No differences exist in the groups between the mean time required to complete COS (11.38 ± 0.360 vs 12.17 ± 0.309; p = 0.11) and mean number of frozen oocytes (8.458 ± 1.060 vs 10.30 ± 0.919; p = 0.22). Furthermore, in the second period, the number of patients who accepted fertility preservation increased (46.15% vs 64.38%; p<0.05).

Conclusions

Renewed organization of the Oncofertility Unit and the newest random-start COS protocol allowed us to shorten the time for oocyte cryopreservation and start anticancer treatment on time.

Article History

Disclosures

Financial support: No financial support was received for this submission.
Conflict of interest: None of the authors has conflict of interest with this submission.

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Authors

Affiliations

  • Obstetrics and Gynecology Unit, San Raffaele Scientific Intitute, Milan - Italy
  • Vita-Salute San Raffaele University, Milan - Italy
  • Clinical and Health Psychology Unit, IRCCS San Raffaele Hospital, Milan - Italy

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