Radiotherapy (RT) plays a central role in the management of cancers located in the abdomen and pelvis. However, radiation-induced toxicity remains a major concern for patients receiving RT to the abdominopelvic region. In this context, our study aims to evaluate the use of transforming growth factor (TGF)-β2-enriched formula for amelioration of radiation-induced diarrhea for patients undergoing pelvic RT.
Between September 2013 and September 2014, 86 malnourished patients undergoing RT for pelvic cancers who received oral nutritional supplementation with or without TGF-β2-enriched formula were assessed retrospectively in 3 groups. Oral diphenoxylate-atropine tablets were used at onset of diarrhea in all groups. Kruskal-Wallis and chi-square tests were used in the comparison of continuous and categorical variables, respectively.
Patients receiving nutritional supplemention with TGF-β2-enriched formula (groups I and II) experienced a significantly lower median number of diarrhea episodes compared to patients receiving nutritional supplementation with other products (group III), which was statistically significant (p<0.05). Also, number of patients experiencing grade 2 and grade 3 diarrhea was significantly lower in groups I and II compared to group III (p<0.05).
Nutritional supplemention with TGF-β2-enriched formula offers amelioration of radiation-induced diarrhea for patients receiving pelvic RT. Since this is the first study assessing the use of nutritional supplementation with TGF-β2-enriched formula for patients undergoing pelvic RT, future prospective studies are needed to confirm the results.
Tumori 2015; 101(5): 474 - 477
Article Type: ORIGINAL RESEARCH ARTICLE
AuthorsSelcuk Demiral, Murat Beyzadeoglu, Omer Sager, Ferrat Dincoglan, Bora Uysal, Hakan Gamsiz, Mustafa Akin, Turker Turker
- • Accepted on 14/01/2015
- • Available online on 12/05/2015
- • Published in print on 09/09/2015
This article is available as full text PDF.
- Demiral, Selcuk [PubMed] [Google Scholar] 1, * Corresponding Author (email@example.com)
- Beyzadeoglu, Murat [PubMed] [Google Scholar] 1
- Sager, Omer [PubMed] [Google Scholar] 1
- Dincoglan, Ferrat [PubMed] [Google Scholar] 1
- Uysal, Bora [PubMed] [Google Scholar] 1
- Gamsiz, Hakan [PubMed] [Google Scholar] 1
- Akin, Mustafa [PubMed] [Google Scholar] 1
- Turker, Turker [PubMed] [Google Scholar] 2
Department of Radiation Oncology, Gulhane Military Medical Academy, Ankara - Turkey
Department of Public Health, Division of Epidemiology, Gulhane Military Medical Academy, Ankara - Turkey