The pathological features of melanoma biopsies can provide significant prognostic information that can help the surgeon evaluate the risk of nodal disease. The aim of this study was to attempt to determine the relationship between pathological features of primary melanoma and nodal disease, by sentinel node biopsy (SNB) and complete node dissection (CND).
A retrospective analysis was completed of patients who underwent SNB at AC Camargo Cancer Center, São Paulo, Brazil, between 2000 and 2010.
A total of 697 patients were evaluated. By univariate analysis, it was found that histology, Clark level, Breslow depth, mitotic index, ulceration, regression, lymphatic and perineural invasion and satellitosis were significantly associated with SNB positivity. In the multivariate analysis, it was found that Breslow depth, mitotic index, ulceration, regression, lymphatic invasion and satellitosis were significant factors. In patients with a positive SNB, the primary tumor site, Clark level and Breslow depth greater than 2 mm were significantly related to non-sentinel node (NSN) positivity by univariate analysis. By multivariate analysis, Breslow depth greater than 2 mm was the only primary tumor feature that was significantly related (p = 0.038).
The indication of SNB should not be based solely on Breslow depth and ulceration or mitotic index. A complete evaluation of the pathological report should improve the identification of high-risk patients.
Tumori 2015; 101(5): 501 - 505
Article Type: ORIGINAL RESEARCH ARTICLE
AuthorsEduardo Bertolli, Mariana Petaccia de Macedo, Clóvis Antonio Lopes Pinto, Aline Santos Damascena, André Sapata Molina, Patrícia Sayuri Ueno, João Pedreira Duprat Neto
- • Accepted on 28/02/2015
- • Available online on 12/05/2015
- • Published in print on 09/09/2015
This article is available as full text PDF.
- Bertolli, Eduardo [PubMed] [Google Scholar] 1, * Corresponding Author (email@example.com)
- de Macedo, Mariana Petaccia [PubMed] [Google Scholar] 2
- Pinto, Clóvis Antonio Lopes [PubMed] [Google Scholar] 2
- Damascena, Aline Santos [PubMed] [Google Scholar] 3
- Molina, André Sapata [PubMed] [Google Scholar] 1
- Ueno, Patrícia Sayuri [PubMed] [Google Scholar] 4
- Neto, João Pedreira Duprat [PubMed] [Google Scholar] 1
Skin Cancer Department, AC Camargo Cancer Center, São Paulo, SP - Brazil
Pathology Department, AC Camargo Cancer Center, São Paulo, SP - Brazil
Department of Statistics, International Center for Research, AC Camargo Cancer Center, São Paulo, SP - Brazil
School of Medicine, Santa Casa de São Paulo, São Paulo, SP - Brazil