Ethnic difference in risk of toxicity in prostate cancer patients treated with dynamic arc radiation therapy


Aims and background

The objective of this study was to assess the influence of ethnicity on toxicity in patients treated with dynamic arc radiation therapy (ART) for prostate cancer (PC).


From June 2006 to May 2012, 162 cT1-T3 cN0 cM0 PC patients were treated with ART (primary diagnosis, n = 125; post-prostatectomy/brachytherapy biochemical recurrence, n = 26; adjuvant post-prostatectomy, n = 11) at 2 institutions. Forty-five patients were Latin Americans and 117 were Europeans. The dose prescribed to the prostate ranged between 68 Gy and 81 Gy.


The median age was 69 years (range 43-87 years). The median follow-up was 18 months (range 2-74 months). Overall, only 3 patients died, none due to a cancer-related cause. Biochemical recurrence was seen in 7 patients. The rates of acute grade 2 gastrointestinal (GI) and genitourinary (GU) toxicities were 19.7% and 17%, respectively. Only 1 patient experienced acute grade 3 GI toxicity, whereas 11 patients (6.7%) experienced acute grade 3 GU toxicity. Multivariate analysis showed that undergoing whole pelvic lymph node irradiation was associated with a higher grade of acute GI toxicity (OR: 3.46; p = 0.003). In addition, older age was marginally associated with a higher grade of acute GI toxicity (OR: 2.10; p = 0.074). Finally, ethnicity was associated with acute GU toxicity: Europeans had lower-grade toxicity (OR: 0.27; p = 0.001).


Our findings suggest an ethnic difference in GU toxicity for PC patients treated with ART. In addition, we found that ART is associated with a very low risk of severe toxicity and a low recurrence rate.

Tumori 2015; 101(4): 461 - 468




Jose L. Lopez Guerra, Raul Matute, Fernando Puebla, Alberto Sánchez-Reyes, Beatriz Pontes, Cristina Rubio, Isabel Nepomuceno, Catalina Acevedo, Nicolas Isa, Rafael Lengua, Juan Manuel Praena-Fernandez, Eleonor Rivin del Campo, Maria Jose Ortiz, Ignacio Azinovic

Article History


Financial support: None.
Conflict of interest: The authors have no conflicts of interest related to this study.

This article is available as full text PDF.

  • If you are a Subscriber, please log in now.

  • Article price: Eur 36,00
  • You will be granted access to the article for 72 hours and you will be able to download any format (PDF or ePUB). The article will be available in your login area under "My PayPerView". You will need to register a new account (unless you already own an account with this journal), and you will be guided through our online shop. Online purchases are paid by Credit Card through PayPal.
  • If you are not a Subscriber you may:
  • Subscribe to this journal
  • Unlimited access to all our archives, 24 hour a day, every day of the week.



  • Department of Radiation Oncology, University Hospital Virgen del Rocio, Sevilla - Spain
  • Master in Advanced Technological Applications in Radiation Oncology, University of Murcia and Grupo IMO Foundation, Madrid - Spain
  • Department of Radiation Oncology, Oncology Institute of Madrid/Grupo IMO, Madrid - Spain
  • Department of Radiation Oncology, San Carlos Clinical Hospital, Madrid - Spain
  • Radiation Physics, Oncology Institute of Madrid/Grupo IMO, Madrid - Spain
  • Department of Computer Language and Systems, University of Sevilla, Sevilla - Spain
  • Department of Radiation Oncology, Valle del Lili Foundation, Cali - Colombia
  • Department of Radiation Oncology, National Cancer Institution, Santiago de Chile - Chile
  • Department of Radiation Oncology, Hope International Hospital, Guatemala - Guatemala
  • Methodology Unit, Andalusian Public Foundation for Research Management in Healthcare of Sevilla, Virgen del Rocío University Hospital, Sevilla - Spain
  • Department of Radiation Oncology, Gustave Roussy Cancer Campus, Villejuif, Paris - France

Article usage statistics

The blue line displays unique views in the time frame indicated.
The yellow line displays unique downloads.
Views and downloads are counted only once per session.

No supplementary material is available for this article.