TNF-α and LT-α polymorphisms and the risk of leukemia: a meta-analysis



The aim of this study is to investigate whether TNF-α or LT-α polymorphisms are associated with the risk of leukemia.


A meta-analysis was performed to examine the association between the TNF-α -308 G>A and LT-α +252 A>G polymorphisms and the incidence of leukemia. We also performed subgroup analyses based on the classification of leukemias. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to evaluate the association.


A total of 19 publications comprising 1,509 cases and 4,075 controls were selected in the study. An association between the risk of leukemia and the LT-α +252 AA genotype was found (GG + AG vs. AA, OR = 0.485, 95% CI 0.368-0.639, p = 0.000). After multivariable analysis TNF-α polymorphism showed no consistent association with leukemia.


This meta-analysis suggests that the LT-α +252 AA polymorphism is associated with the risk of leukemia.

Tumori 2017; 103(1): 53 - 59




Li-li Gong, Fei-fei Han, Ya-li Lv, He Liu, Zi-rui Wan, Wen Zhang, Ming-biao Shi, Li-xia Pei, Li-hong Liu

Article History


Financial support: This study was supported by the National Natural Science Foundation of China (No. 81302822), Beijing Municipal Administration of Hospitals’ Youth Programme (No. QML20150302), and National Natural Science Foundation of China (No. 81303187).
Conflict of interest: We declare that we have no conflict of interest.

This article is available as full text PDF.

  • If you are a Subscriber, please log in now.

  • Article price: Eur 36,00
  • You will be granted access to the article for 72 hours and you will be able to download any format (PDF or ePUB). The article will be available in your login area under "My PayPerView". You will need to register a new account (unless you already own an account with this journal), and you will be guided through our online shop. Online purchases are paid by Credit Card through PayPal.
  • If you are not a Subscriber you may:
  • Subscribe to this journal
  • Unlimited access to all our archives, 24 hour a day, every day of the week.



  • Beijing Chao-Yang Hospital, Capital Medical University, Beijing - China

Article usage statistics

The blue line displays unique views in the time frame indicated.
The yellow line displays unique downloads.
Views and downloads are counted only once per session.

No supplementary material is available for this article.