The aim of this study is to investigate whether TNF-α or LT-α polymorphisms are associated with the risk of leukemia.
A meta-analysis was performed to examine the association between the TNF-α -308 G>A and LT-α +252 A>G polymorphisms and the incidence of leukemia. We also performed subgroup analyses based on the classification of leukemias. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to evaluate the association.
A total of 19 publications comprising 1,509 cases and 4,075 controls were selected in the study. An association between the risk of leukemia and the LT-α +252 AA genotype was found (GG + AG vs. AA, OR = 0.485, 95% CI 0.368-0.639, p = 0.000). After multivariable analysis TNF-α polymorphism showed no consistent association with leukemia.
This meta-analysis suggests that the LT-α +252 AA polymorphism is associated with the risk of leukemia.
Tumori 2017; 103(1): 53 - 59
Article Type: ORIGINAL RESEARCH ARTICLE
AuthorsLi-li Gong, Fei-fei Han, Ya-li Lv, He Liu, Zi-rui Wan, Wen Zhang, Ming-biao Shi, Li-xia Pei, Li-hong Liu
- • Accepted on 20/07/2016
- • Available online on 01/09/2016
- • Published in print on 21/01/2017
This article is available as full text PDF.
- Gong, Li-li [PubMed] [Google Scholar]
- Han, Fei-fei [PubMed] [Google Scholar]
- Lv, Ya-li [PubMed] [Google Scholar]
- Liu, He [PubMed] [Google Scholar]
- Wan, Zi-rui [PubMed] [Google Scholar]
- Zhang, Wen [PubMed] [Google Scholar]
- Shi, Ming-biao [PubMed] [Google Scholar]
- Pei, Li-xia [PubMed] [Google Scholar]
- Liu, Li-hong [PubMed] [Google Scholar] , * Corresponding Author (firstname.lastname@example.org)
Beijing Chao-Yang Hospital, Capital Medical University, Beijing - China