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TNF-α and LT-α polymorphisms and the risk of leukemia: a meta-analysis

Abstract

Aim

The aim of this study is to investigate whether TNF-α or LT-α polymorphisms are associated with the risk of leukemia.

Methods

A meta-analysis was performed to examine the association between the TNF-α -308 G>A and LT-α +252 A>G polymorphisms and the incidence of leukemia. We also performed subgroup analyses based on the classification of leukemias. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to evaluate the association.

Results

A total of 19 publications comprising 1,509 cases and 4,075 controls were selected in the study. An association between the risk of leukemia and the LT-α +252 AA genotype was found (GG + AG vs. AA, OR = 0.485, 95% CI 0.368-0.639, p = 0.000). After multivariable analysis TNF-α polymorphism showed no consistent association with leukemia.

Conclusions

This meta-analysis suggests that the LT-α +252 AA polymorphism is associated with the risk of leukemia.

Tumori 2017; 103(1): 53 - 59

Article Type: ORIGINAL RESEARCH ARTICLE

DOI:10.5301/tj.5000549

Authors

Li-li Gong, Fei-fei Han, Ya-li Lv, He Liu, Zi-rui Wan, Wen Zhang, Ming-biao Shi, Li-xia Pei, Li-hong Liu

Article History

Disclosures

Financial support: This study was supported by the National Natural Science Foundation of China (No. 81302822), Beijing Municipal Administration of Hospitals’ Youth Programme (No. QML20150302), and National Natural Science Foundation of China (No. 81303187).
Conflict of interest: We declare that we have no conflict of interest.

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Authors

Affiliations

  • Beijing Chao-Yang Hospital, Capital Medical University, Beijing - China

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