High-dose chemotherapy (HDCT) and autologous stem cell transplantation (ASCT) is used to treat patients with relapsed Hodgkin’s lymphoma. In this retrospective study we report our experience with patients who underwent HDCT and ASCT.
All patients ≥15 years old with relapsed/refractory Hodgkin’s lymphoma who underwent HDCT and ASCT between June 2001 and December 2013 were included.
Fifty-four patients were identified. Median age at transplant was 22 years (range 15-49 years); 26 were men and 28 were women. Forty-eight patients (89%) underwent HDCT and ASCT after achieving a radiological response to salvage chemotherapy. The rate of radiological complete response to salvage chemotherapy was 13% and reached 50% within 3 months of ASCT in assessable patients. After a median follow-up of 25 months, 31 patients (57%) were still alive with no evidence of relapse or progression. Median event-free survival (EFS) was 24 months (95% CI 8.7-39.3) and 3-year EFS was 56%. Median overall survival (OS) was not reached and 3-year OS was 82.5%. Bulky mediastinal disease at relapse, hemoglobin level, and number of salvage regimens did not significantly impact EFS in univariate and multivariate analyses. After transplantation there was a trend towards longer EFS (30 vs. 24 months; p = 0.36) in patients with a longer time from the end of first-line treatment until relapse (≥12 vs. <12 months). The 100-day transplant-related mortality was 5.5%.
HDCT and ASCT for relapsed/refractory Hodgkin’s lymphoma is safe. Our findings are consistent with published phase III results. Longer follow-up is warranted.
Post author correction
Article Type: ORIGINAL RESEARCH ARTICLE
AuthorsMouhammed Kelta, Jamal Zekri, Ehab Abdelghany, Jalil Ur Rehman, Zahid Amin Khan, Rawan Al-Saadi, Reyad Dada
- • Accepted on 15/11/2016
- • Available online on 19/12/2016
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- Kelta, Mouhammed [PubMed] [Google Scholar] 1, * Corresponding Author (email@example.com)
- Zekri, Jamal [PubMed] [Google Scholar] 1, 2
- Abdelghany, Ehab [PubMed] [Google Scholar] 1, 3
- Rehman, Jalil Ur [PubMed] [Google Scholar] 1
- Khan, Zahid Amin [PubMed] [Google Scholar] 1
- Al-Saadi, Rawan [PubMed] [Google Scholar] 1
- Dada, Reyad [PubMed] [Google Scholar] 1, 2
Department of Oncology, King Faisal Specialist Hospital & Research Center, Jeddah - Saudi Arabia
College of Medicine, Al-Faisal University, Riyadh - Saudi Arabia
National Cancer Institute, Cairo University, Cairo - Egypt
Mouhammed Kelta and Jamal Zekri contributed equally to this work.