Radical cystectomy (RC) is the main treatment option for patients with muscle-invasive bladder cancer (MIBC) and non-muscle-invasive bladder cancer (NMIBC), which carry the highest risk of progression. In this study, we investigated the effect of time from transurethral resection of the bladder (TUR-B) to cystectomy on lymph node positivity, cancer-specific survival and overall survival in patients with MIBC.
The records were reviewed of 530 consecutive patients who had RC and pelvic lymphadenectomy procedures with curative intent performed by selected surgeons between May 2005 and April 2016. Our analysis included only patients with transitional cell carcinoma of the bladder; we excluded 23 patients with other types of tumor histology.
Patients who underwent delayed RC were compared with patients who were treated with early RC; both groups were similar in terms of age, gender, T stage, tumor grade, tumor differentiation, lymph node status and metastasis status. However, when both groups were compared for disease-free survival and overall survival, patients of the early-RC group had a greater advantage.
The optimal time between the last TUR-B and RC is still controversial. A reasonable time for preoperative preparation can be allowed, but long delays, especially those exceeding 3 months, can lead to unfavorable outcomes in cancer control.
Post author correction
Article Type: ORIGINAL RESEARCH ARTICLE
AuthorsHakan Türk, Sıtkı Ün, Ahmet Cinkaya, Hilmi Kodaz, Murtaza Parvizi, Ferruh Zorlu
- • Accepted on 14/04/2017
- • Available online on 19/06/2017
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- Türk, Hakan [PubMed] [Google Scholar] 1, * Corresponding Author (firstname.lastname@example.org)
- Ün, Sıtkı [PubMed] [Google Scholar] 2
- Cinkaya, Ahmet [PubMed] [Google Scholar] 3
- Kodaz, Hilmi [PubMed] [Google Scholar] 4
- Parvizi, Murtaza [PubMed] [Google Scholar] 5
- Zorlu, Ferruh [PubMed] [Google Scholar] 6
Department of Urology, Evliya Celebi Training and Research Hospital, Kütahya - Turkey
Department of Urology, Sivas State Hospital, Sivas - Turkey
Department of Radiation Oncology, Faculty of Medicine, Dumlupınar University, Kütahya - Turkey
Department of Medical Oncology, Faculty of Medicine, Trakya University, Edirne - Turkey
Department of Radiation Oncology, Manisa State Hospital, Manisa - Turkey
Department of Urology, Tepecik Training and Research Hospital, İzmir - Turkey