Elderly patients with uterine cervical cancer reportedly have a poorer prognosis than younger patients. Until now, the benefit of concurrent chemoradiotherapy (CCRT) for elderly patients has been considered limited.
We retrospectively analyzed 49 women with cervical cancer aged >70 years primarily treated with radiotherapy (RT) or CCRT in our institute between 2003 and 2014. Treatment compliance, toxicity, and survival benefit were analyzed.
A total of 49 patients were identified in this retrospective analysis. Twenty patients with a median age of 75.4 years (range 70-77) were treated with CCRT and 29 patients with a median age of 77.9 years (range 70-89) underwent RT. In the CCRT group, 14 patients (70%) completed CCRT consisting of radiotherapy and 5 courses of cisplatin plus 5-fluorouracil including patients requiring a dose reduction of chemotherapy. The median overall survival (OS) in the CCRT and RT groups was 66.9 and 60.1 months, respectively (p = 0.156). The most common grade 3/4 acute toxicity was hyponatremia (35.0%), followed by neutropenia (15.0%) and diarrhea (10.0%) in the CCRT group, while this was anemia (17.2%) followed by radiation enteritis (10.3%) in the RT group.
CCRT was well tolerated in elderly patients with cervical cancer. Careful attention should be paid to the different characteristics of treatment-related toxicities in this group compared with younger patients.
Tumori 2016; 102(6): 600 - 605
Article Type: ORIGINAL RESEARCH ARTICLE
AuthorsKazuto Nosaka, Kiyosumi Shibata, Fumi Utsumi, Kosuke Yoshida, Kaoru Niimi, Ryuichiro Sekiya, Shiro Suzuki, Hiroaki Kajiyama, Fumitaka Kikkawa
- • Accepted on 25/05/2016
- • Available online on 19/07/2016
- • Published in print on 01/12/2016
This article is available as full text PDF.
- Nosaka, Kazuto [PubMed] [Google Scholar]
- Shibata, Kiyosumi [PubMed] [Google Scholar] , * Corresponding Author (firstname.lastname@example.org)
- Utsumi, Fumi [PubMed] [Google Scholar]
- Yoshida, Kosuke [PubMed] [Google Scholar]
- Niimi, Kaoru [PubMed] [Google Scholar]
- Sekiya, Ryuichiro [PubMed] [Google Scholar]
- Suzuki, Shiro [PubMed] [Google Scholar]
- Kajiyama, Hiroaki [PubMed] [Google Scholar]
- Kikkawa, Fumitaka [PubMed] [Google Scholar]
Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya - Japan