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Feasibility and benefit of concurrent chemoradiotherapy for elderly patients with uterine cervical cancer

Abstract

Background

Elderly patients with uterine cervical cancer reportedly have a poorer prognosis than younger patients. Until now, the benefit of concurrent chemoradiotherapy (CCRT) for elderly patients has been considered limited.

Methods

We retrospectively analyzed 49 women with cervical cancer aged >70 years primarily treated with radiotherapy (RT) or CCRT in our institute between 2003 and 2014. Treatment compliance, toxicity, and survival benefit were analyzed.

Results

A total of 49 patients were identified in this retrospective analysis. Twenty patients with a median age of 75.4 years (range 70-77) were treated with CCRT and 29 patients with a median age of 77.9 years (range 70-89) underwent RT. In the CCRT group, 14 patients (70%) completed CCRT consisting of radiotherapy and 5 courses of cisplatin plus 5-fluorouracil including patients requiring a dose reduction of chemotherapy. The median overall survival (OS) in the CCRT and RT groups was 66.9 and 60.1 months, respectively (p = 0.156). The most common grade 3/4 acute toxicity was hyponatremia (35.0%), followed by neutropenia (15.0%) and diarrhea (10.0%) in the CCRT group, while this was anemia (17.2%) followed by radiation enteritis (10.3%) in the RT group.

Conclusions

CCRT was well tolerated in elderly patients with cervical cancer. Careful attention should be paid to the different characteristics of treatment-related toxicities in this group compared with younger patients.

Tumori 2016; 102(6): 600 - 605

Article Type: ORIGINAL RESEARCH ARTICLE

DOI:10.5301/tj.5000530

Authors

Kazuto Nosaka, Kiyosumi Shibata, Fumi Utsumi, Kosuke Yoshida, Kaoru Niimi, Ryuichiro Sekiya, Shiro Suzuki, Hiroaki Kajiyama, Fumitaka Kikkawa

Article History

Disclosures

Financial support: None.
Conflict of interest: None.

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Authors

Affiliations

  • Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya - Japan

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