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Diffusion-weighted magnetic resonance imaging in patients with prostate cancer treated with radiotherapy

Abstract

Aims

To evaluate the utility of a multiparametric 3T magnetic resonance imaging (MRI) study using diffusion-weighted images (DWI) for the assessment of prostate cancer before and after radiotherapy (RT).

Methods

A total of 34 patients, who received a histologic diagnosis of prostate adenocarcinoma, underwent MRI examination before and after local RT for the assessment of response to treatment. Apparent diffusion coefficient (ADC) values were calculated and compared.

Results

Before RT, DWI shows pathologic restriction of signal, while after RT pathologic restriction of signal was reduced or disappeared. The ADC values were significantly increased after therapy (p<0.05).

Conclusions

The use of DWI with ADC measurements may be an imaging biomarker in the assessment of prostate cancer.

Tumori 2016; 102(1): 71 - 76

Article Type: ORIGINAL RESEARCH ARTICLE

DOI:10.5301/tj.5000415

Authors

Giancarlo Iannelli, Rocchina Caivano, Luciana Rago, Vittorio Simeon, Antonella Lotumolo, Paola Rabasco, Antonio Villonio, Matilde Gioioso, Pietro Mastrangelo, Flavio Barchetti, Valeria Panebianco, Luca Macarini, Giuseppe Guglielmi, Aldo Cammarota

Article History

Disclosures

Financial support: None.
Conflict of interest: None.

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Authors

Affiliations

  • Radiology Department, IRCCS-CROB, Rionero in Vulture (Potenza) - Italy
  • Department of Radiological Sciences, Oncology and Pathology, Prostate Unit Diagnostic University of Rome, “La Sapienza,” Rome - Italy
  • Department of Radiology, University of Foggia, Foggia - Italy
  • Department of Radiology, Scientific Institute Hospital “Casa Sollievo della Sofferenza,” San Giovanni Rotondo (Foggia) - Italy
  • Giancarlo Iannelli and Rocchina Caivano contributed equally to this work.

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