Diffusion-weighted magnetic resonance imaging in patients with prostate cancer treated with radiotherapy



To evaluate the utility of a multiparametric 3T magnetic resonance imaging (MRI) study using diffusion-weighted images (DWI) for the assessment of prostate cancer before and after radiotherapy (RT).


A total of 34 patients, who received a histologic diagnosis of prostate adenocarcinoma, underwent MRI examination before and after local RT for the assessment of response to treatment. Apparent diffusion coefficient (ADC) values were calculated and compared.


Before RT, DWI shows pathologic restriction of signal, while after RT pathologic restriction of signal was reduced or disappeared. The ADC values were significantly increased after therapy (p<0.05).


The use of DWI with ADC measurements may be an imaging biomarker in the assessment of prostate cancer.

Tumori 2016; 102(1): 71 - 76




Giancarlo Iannelli, Rocchina Caivano, Luciana Rago, Vittorio Simeon, Antonella Lotumolo, Paola Rabasco, Antonio Villonio, Matilde Gioioso, Pietro Mastrangelo, Flavio Barchetti, Valeria Panebianco, Luca Macarini, Giuseppe Guglielmi, Aldo Cammarota

Article History


Financial support: None.
Conflict of interest: None.

This article is available as full text PDF.

  • If you are a Subscriber, please log in now.

  • Article price: Eur 36,00
  • You will be granted access to the article for 72 hours and you will be able to download any format (PDF or ePUB). The article will be available in your login area under "My PayPerView". You will need to register a new account (unless you already own an account with this journal), and you will be guided through our online shop. Online purchases are paid by Credit Card through PayPal.
  • If you are not a Subscriber you may:
  • Subscribe to this journal
  • Unlimited access to all our archives, 24 hour a day, every day of the week.



  • Radiology Department, IRCCS-CROB, Rionero in Vulture (Potenza) - Italy
  • Department of Radiological Sciences, Oncology and Pathology, Prostate Unit Diagnostic University of Rome, “La Sapienza,” Rome - Italy
  • Department of Radiology, University of Foggia, Foggia - Italy
  • Department of Radiology, Scientific Institute Hospital “Casa Sollievo della Sofferenza,” San Giovanni Rotondo (Foggia) - Italy
  • Giancarlo Iannelli and Rocchina Caivano contributed equally to this work.

Article usage statistics

The blue line displays unique views in the time frame indicated.
The yellow line displays unique downloads.
Views and downloads are counted only once per session.

No supplementary material is available for this article.