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Polymorphism rs144848 in BRCA2 may reduce lung cancer risk in women: a case-control study in southeast China

Abstract

Purpose

Whereas lung cancer incidence among men has declined in recent years, the incidence rate among women has increased rapidly. Sex could affect DNA repair capacity. Although BRCA2 is important in DNA repair, few data are available on the association between BRCA2 polymorphisms and lung cancer in women. Therefore, we investigated this in a case-control study among Chinese women.

Methods

We enrolled 226 women with lung cancer and 269 age-matched healthy controls in our study. Polymorphisms studied were genotyped by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.

Results

Unconditional logistic regression showed no association between rs1799943 or rs1799944 and cancer risk. However, the AC and CC genotypes of rs144848 were significantly associated with reduced risk after adjustment for age and education, with adjusted odds ratios (ORs) of 0.66 (95% confidence interval [CI] 0.45-0.97) and 0.37 (95% CI 0.16-0.78), respectively. The adjusted OR of carriers with the C allele was 0.62 (95% CI 0.44-0.81) compared with the A allele.

Conclusions

The rs144848 mutation may have a protective effect against lung cancer among women.

Tumori 2016; 102(2): 150 - 155

Article Type: ORIGINAL RESEARCH ARTICLE

DOI:10.5301/tj.5000473

Authors

Yong Lin, Fei He, Xin Zhang, Tingting Yu, Zhiqiang Liu, Lin Cai

Article History

Disclosures

Financial support: Supported by grants from the National Natural Science Foundation of China (no. 30771845 and no. 81172766).
Conflict of interest: None of the authors has conflict of interest with this submission.

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Authors

Affiliations

  • School of Public Health, Fujian Medical University, Fuzhou, Fujian Province - People’s Republic of China

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