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CYP1A1 Ile462Val polymorphism and the risk of non-small cell lung cancer in a Chinese population

Abstract

Aims and background. Cytochrome P450 (CYP) 1A1 enzyme plays an important role in the metabolism of carcinogens, such as polycyclic aromatic hydrocarbons, nitroaromatics and arylamines.
Methods. The study examined the association of CYP1A1 Ile462Val polymorphism with the risk of developing non-small cell lung cancer in a Chinese population. We conducted a case-control study including 526 non-small cell lung cancer cases and 526 cancer-free controls. The odds ratios and 95 confidence intervals were calculated by logistic regression models.
Results. Compared with 462Ile/Ile genotype carriers, subjects with CYP1A1 462Ile/Val or Val/Val genotype had a decreased risk of developing non-small cell lung cancer with odds ratios of 0.57 (95% CI, 0.44-0.75) and 0.54 (95% CI, 0.36-0.81), respectively. When stratified by smoking status, the decreased risk of non-small cell lung cancer associated with CYP1A1 462Ile/Val or Val/Val genotype was observed among nonsmokers (OR = 0.62, 95% CI, 0.45-0.87) and among smokers (OR = 0.54, 95% CI, 0.37- 0.78). When stratified by smoking-dose, the correlation between CYP1A1 genotypes and the risk of non-small cell lung cancer was detected among light smokers (OR = 0.30, 95% CI, 0.19-0.48) but not among heavy smokers (OR = 0.93, 95% CI, 0.61-1.43).
Conclusions. The CYP1A1 Ile462Val variant was associated with a low risk of developing non-small cell lung cancer in a Chinese population.

Tumori 2014; 100(5): 547 - 552

Article Type: ORIGINAL RESEARCH ARTICLE

DOI:10.1700/1660.18178

Authors

Jia Lin, Bing He, Lei Cao, Zhi Zhang, Hongmei Liu, Juan Rao, Yingwen Liu, Shasha Shao, Guangxia Wang, Xuemei Zhang

Article History

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Authors

  • Lin, Jia [PubMed] [Google Scholar]
    Department of Molecular Genetics, College of Life Science, Hebei United University, Tangshan
  • He, Bing [PubMed] [Google Scholar]
    Department of Molecular Genetics, College of Life Science, Hebei United University, Tangshan
  • Cao, Lei [PubMed] [Google Scholar]
    Department of Molecular Genetics, College of Life Science, Hebei United University, Tangshan
  • Zhang, Zhi [PubMed] [Google Scholar]
    Department of Cancer Chemotherapy and Radiology, Tangshan Gongren Hospital, Tangshan, China
  • Liu, Hongmei [PubMed] [Google Scholar]
    Department of Cancer Chemotherapy and Radiology, Tangshan Gongren Hospital, Tangshan, China
  • Rao, Juan [PubMed] [Google Scholar]
    Department of Molecular Genetics, College of Life Science, Hebei United University, Tangshan
  • Liu, Yingwen [PubMed] [Google Scholar]
    Department of Molecular Genetics, College of Life Science, Hebei United University, Tangshan
  • Shao, Shasha [PubMed] [Google Scholar]
    Department of Cancer Chemotherapy and Radiology, Tangshan Gongren Hospital, Tangshan, China
  • Wang, Guangxia [PubMed] [Google Scholar]
    Department of Cancer Chemotherapy and Radiology, Tangshan Gongren Hospital, Tangshan, China
  • Zhang, Xuemei [PubMed] [Google Scholar]
    Department of Molecular Genetics, College of Life Science, Hebei United University, Tangshan

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