Keratinocyte growth factor (KGF) is reported to be implicated in the growth of some cancer cells. Matrix metalloproteinase 9 (MMP-9) is thought to enhance the tumor invasion and metastasis ability. This study was aimed at analyzing the relationship between KGF and MMP-9 expression and patients’ clinicopathological characteristics to clarify the clinical significance of the expression of KGF and MMP-9 in gastric cancer.
Tissue samples from 161 patients with primary gastric cancer were investigated using immunohistochemistry. The relationship between KGF and/or MMP-9 expression and clinicopathological characteristics was analyzed.
KGF expression and MMP-9 expression in gastric cancer tissue were observed in 62 cases (38.5%) and 97 cases (60.2%), respectively. MMP-9 was significantly associated with depth of invasion, lymph node metastasis and TNM stage. The prognosis of MMP-9-positive patients was significantly poorer than that of MMP-9-negative patients (p = 0.009). KGF expression was positively correlated with MMP-9 expression in gastric cancer, and the prognosis of patients with both KGF- and MMP-9-positive tumors was significantly worse than that of patients with negative tumors for either factor (p = 0.045). Expression of MMP-9 was revealed to be an independent prognostic factor (p = 0.026).
Coexpression of KGF and MMP-9 in gastric cancer could be a useful prognostic factor, and MMP-9 might also serve as a novel target for both prognostic prediction and therapeutics.
Tumori 2015; 101(5): 566 - 571
Article Type: ORIGINAL RESEARCH ARTICLE
AuthorsQing Zhang, Ping Wang, Ming Shao, Shi-Wen Chen, Zhi-Feng Xu, Feng Xu, Zhong-Yin Yang, Bing-Ya Liu, Qin-Long Gu, Wen-Jian Zhang, Yong Li
- • Accepted on 22/05/2015
- • Available online on 03/08/2015
- • Published in print on 09/09/2015
This article is available as full text PDF.
- Zhang, Qing [PubMed] [Google Scholar] 1
- Wang, Ping [PubMed] [Google Scholar] 2
- Shao, Ming [PubMed] [Google Scholar] 3
- Chen, Shi-Wen [PubMed] [Google Scholar] 1
- Xu, Zhi-Feng [PubMed] [Google Scholar] 1
- Xu, Feng [PubMed] [Google Scholar] 1
- Yang, Zhong-Yin [PubMed] [Google Scholar] 4
- Liu, Bing-Ya [PubMed] [Google Scholar] 4
- Gu, Qin-Long [PubMed] [Google Scholar] 4
- Zhang, Wen-Jian [PubMed] [Google Scholar] 5
- Li, Yong [PubMed] [Google Scholar] 1, * Corresponding Author (firstname.lastname@example.org)
Department of Medical Oncology, GongLi Hospital, Shanghai - China
Department of Pathology, Shanghai Ninth People’s Hospital, Affiliated Shanghai Jiao Tong University, School of Medicine, Shanghai - China
Department of Gastroenterology, The Second Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui Province - China
Department of General Surgery, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai - China
Shandong University, School of Medicine, Jinan, Shandong Province - China
Qing Zhang, Ping Wang and Ming Shao contributed equally to this work. Ping Wang and Ming Shao as co-first author