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Chronic lymphocytic leukemia–associated refractory immune thrombocytopenia successfully treated with eltrombopag

Abstract

Chronic lymphocytic leukemia (CLL) may be associated with immune thrombocytopenia (ITP). The standard treatment for CLL-associated ITP is steroids. For refractory cases, various treatment strategies such as rituximab, splenectomy, and thrombopoietic mimetics are available. We report a patient with CLL who developed recurrent ITP and life-threatening pulmonary hemorrhage. Platelet counts remained extremely low despite massive platelet transfusion and treatment including steroids, immunoglobulin, and single-dose rituximab infusion. The bleeding stopped and platelet counts were increased to normal range 13 days after treatment with eltrombopag 25 mg per day. Our experience suggests that eltrombopag is an effective treatment option in CLL-associated, refractory ITP, especially during major bleeding, which requires relatively rapid improvement of thrombocytopenia.

Tumori 2015; 101(2): e49 - e50

Article Type: CASE REPORT

DOI:10.5301/je.5000248

Authors

Hung Chang, Lee-Yung Shih

Article History

Disclosures

Financial support: No financial support was received for this submission.
Conflict of interest: The authors have no conflict of interest.

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Authors

Affiliations

  • School of Medicine, Chang Gung University, Kweishan Township, Taoyuan - Taiwan
  • Division of Hematology-Oncology, Chang Gung Memorial Hospital, Kweishan Township, Taoyuan - Taiwan

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