Challenges and differences in external radiation therapy for retinoblastoma: from standard techniques to new developments



The purpose of this study is to calculate the treatment plans and to compare the dose distributions and dose-volume histograms (DVH) for 6 external radiotherapy techniques for the treatment of retinoblastoma as well as intensity-modulated radiotherapy (IMRT) and fractionated stereotactic radiotherapy (Cyberknife).


Treatment plans were developed using 6 techniques, including an en face electron technique (ET), an anterior and lateral wedge photon technique (LFT), a 3D conformal (6 fields) technique (CRT), an inverse plan IMRT, tomotherapy, and conventional focal stereotactic external beam radiotherapy with Cyberknife (SBRT). Dose volume analyses were carried out for each technique.


All techniques except electron provided similar target coverage. When comparing conformal plan with IMRT and SBRT, there was no significant difference in planning target volume dose distribution. The mean volume of ipsilateral bony orbit received more than 20 Gy, a suggested threshold for bone growth inhibition. The V20 Gy was 73% for the ET, 57% for the LFT, 87% for the CRT, 65% for the IMRT, 66% for the tomotherapy, and 2.7% for the SBRT.


This work supports the potential use of IMRT and SBRT to spare normal tissues in these patients.

Tumori 2017; 103(5): 438 - 442




Ayşe Hiçsönmez, Yıldız Güney, Ayşen Dizman, Bahar Dirican, Yakup Arslan, Tugba Atakul, Hasan Uysal, Kaan Gündüz, Nurdan Taçyıldız, Emel Ünal, Handan Dinçaslan, Meltem Nalça Andrieu

Article History


Financial support: None.
Conflict of interest: None.

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  • Department of Radiation Oncology, Ankara University School of Medicine, Cebeci Hospital, Ankara - Turkey
  • Department of Radiation Oncology, Ankara Oncology Hospital, Demetevler, Ankara - Turkey
  • Department of Radiation Oncology, Ankara Gülhane Military Medical Academy, Keçiöğren, Ankara - Turkey
  • Department of Ophthalmology, Ankara University School of Medicine, Cebeci Hospital, Ankara - Turkey
  • Department of Pediatric Oncology, Ankara University School of Medicine, Cebeci Hospital, Ankara - Turkey

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