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Case report: long-lasting response in a patient with metastatic renal cell cancer receiving antitumor cytotoxic T lymphocytes

Abstract

Aims and background. Adoptive immunotherapy can be a therapeutic option to treat cancer patients with advanced-stage disease refractory to conventional therapies.
Methods and study design. We used T-cell therapy with autologous antitumor cytotoxic T lymphocytes (CTLs) in a patient with metastatic renal cell carcinoma. Autologous antitumor CTLs obtained by stimulating CD8-enriched cells with dendritic cells pulsed with irradiated apoptotic tumor cells and expanded in vitro were transfused on days +14 and +28 following chemotherapy and every 2 to 4 months thereafter.
Results and conclusions. Treatment with high doses of antitumor CTLs proved to be safe and induced immunological responses and long-lasting clinical benefit in our patient.

Tumori 2013; 99(6): e282 - e284

Article Type: CASE REPORT

DOI:10.1700/1390.15469

Authors

Simona Secondino, Ilaria Turin, Enrica Montini, Camillo Porta, Rita Maccario, Paolo Pedrazzoli, Daniela Montagna

Article History

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Authors

  • Secondino, Simona [PubMed] [Google Scholar]
    Oncology Unit, Fondazione IRCCS Policlinico S Matteo, Pavia, Italy
  • Turin, Ilaria [PubMed] [Google Scholar]
    Laboratory of Transplant Immunology, Fondazione IRCCS Policlinico S Matteo, Pavia, Italy
  • Montini, Enrica [PubMed] [Google Scholar]
    Laboratory of Transplant Immunology, Fondazione IRCCS Policlinico S Matteo, Pavia, Italy
  • Porta, Camillo [PubMed] [Google Scholar]
    Oncology Unit, Fondazione IRCCS Policlinico S Matteo, Pavia, Italy
  • Maccario, Rita [PubMed] [Google Scholar]
    Laboratory of Transplant Immunology, Fondazione IRCCS Policlinico S Matteo, Pavia, Italy
  • Pedrazzoli, Paolo [PubMed] [Google Scholar]
    Oncology Unit, Fondazione IRCCS Policlinico S Matteo, Pavia, Italy
  • Montagna, Daniela [PubMed] [Google Scholar]
    Department of Clinical-Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy

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