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Cardiac metastasis from renal cell carcinoma successfully treated with pazopanib: impact of TKIs’ antiangiogenic activity

Abstract

Cardiac metastasis from renal cell carcinoma, especially without neoplastic thrombosis of the vena cava, is extremely rare. The prognosis of patients with metastatic renal cell carcinoma has been radically influenced by the introduction of tyrosine kinase inhibitors, but very few reports in the literature have described their activity in heart metastasis. We report the case of a woman with a left ventricle metastasis from kidney cancer without renal vein involvement, who was treated with pazopanib. The patient achieved a prolonged partial response, with clear signs of metastasis devascularization and a favorable toxicity profile.

Tumori 2014; 100(6): e298 - e300

Article Type: ORIGINAL RESEARCH ARTICLE

DOI:10.1700/1778.19304

Authors

Giovanni Schinzari, Santa Monterisi, Diego Signorelli, Silvia Cona, Alessandra Cassano, Francesco Danza, Carlo Barone

Article History

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