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Relationship of radiometabolic biomarkers to KRAS mutation status and ALK rearrangements in cases of lung adenocarcinoma

Abstract

Purpose

Rapid diagnosis of genetic mutations is important for targeted therapies such as EGFR tyrosine kinase inhibitors. KRAS mutation and ALK rearrangement are also important in determining treatment. The purpose of our study was to evaluate the diagnostic value of 18F-FDG PET to predict KRAS mutation and ALK rearrangement in order to determine the frequency of these genetic markers in our lung adenocarcinoma cases and contribute to forthcoming meta-analysis studies.

Methods

A total of 218 patients with lung adenocarcinoma (EGFR analyzed) who were seen at our clinic between 2012 and 2014 were included in the study. The results of the 18 F-FDG-PET scans for each patient were retrospectively recorded with the associated medical documents. ALK rearrangements were analyzed in 166 of the 218 patients, while 50 of the 218 patients were analyzed for KRAS mutational status. SPSS 15.0 for Windows was used for statistical analysis.

Results

FDG avidity was higher in cases with KRAS mutations and ALK rearrangements than those without, but the difference was not significant. ALK rearrangements were more common in younger, female, and nonsmoking patients with lung adenocarcinoma.

Conclusions

The small numbers of KRAS mutations and ALK rearrangements are the limitation of this study for evaluation of diagnostic imaging. The frequency of these genetic alterations was as reported in the literature. We believe that our work will contribute to future meta-analysis.

Post author correction

Article Type: ORIGINAL RESEARCH ARTICLE

Article Subject: Thoracic Oncology

DOI:10.5301/tj.5000695

Authors

Gulfidan Aras, Zehra Dilek Kanmaz, Esin Tuncay, Erdoğan Çetinkaya, Esin Yentürk, Celalettin Kocatürk, Büge Öz, Tevfik Fikret Çermik, Sevim Purisa

Article History

Disclosures

Financial support: None.
Conflict of interest: The authors have no conflicts of interest related to this work.

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Authors

Affiliations

  • Yedikule Chest Disease and Training Hospital, Istanbul - Turkey
  • Cerrahpasa Medical Faculty, Pathology Department, Istanbul University, Istanbul - Turkey
  • Department of Nuclear Medicine, Istanbul Training and Research Hospital, Istanbul - Turkey
  • Department of Statistics, Istanbul University, Istanbul - Turkey

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