The purpose of this work was to explore the systematic molecular mechanism of lung adenocarcinoma and gain a deeper insight into it.
Comprehensive bioinformatics methods were applied. Initially, significant differentially expressed genes (DEGs) were analyzed from the Affymetrix microarray data (GSE27262) deposited in the Gene Expression Omnibus (GEO). Subsequently, gene ontology (GO) analysis was performed using online Database for Annotation, Visualization and Integration Discovery (DAVID) software. Finally, significant pathway crosstalk was investigated based on the information derived from the Kyoto Encyclopedia of Genes and Genomes (KEGG) database.
According to our results, the N-terminal globular domain of the type X collagen
Dysfunctional genes and pathways may play key roles in the progression and development of lung adenocarcinoma. Our data provide a systematic perspective for understanding this mechanism and may be helpful in discovering an effective treatment for lung adenocarcinoma.
Tumori 2015; 101(3): 281 - 286
Article Type: ORIGINAL RESEARCH ARTICLE
AuthorsXiya Wu, Wei Zhang, Yunhua Hu, Xianghua Yi
- • Accepted on 30/01/2015
- • Available online on 21/05/2015
- • Published in print on 25/06/2015
This article is available as full text PDF.
- Wu, Xiya [PubMed] [Google Scholar] 1, 2
- Zhang, Wei [PubMed] [Google Scholar] 1
- Hu, Yunhua [PubMed] [Google Scholar] 3
- Yi, Xianghua [PubMed] [Google Scholar] 4, * Corresponding Author (email@example.com)
Department of Respiratory Medicine, The First Hospital of Nanchang University, Nanchang, Jiangxi - PR China
Department of Respiratory Medicine, People’s Hospital of Jiangxi Province, Nanchang, Jiangxi - PR China
Department of Cardiology, People’s Hospital of Jiangxi Province, Nanchang, Jiangxi - PR China
Department of Pathology, Tongji Hospital, Tongji University School of Medicine, Shanghai Tongji Hospital, Shanghai - PR China