Non-small cell lung cancer presents at an advanced stage at diagnosis in two-thirds of cases. The most frequent metastatic sites are the central nervous system, adrenal glands and bones. By contrast, the thyroid gland is an extremely rare site of dissemination.
A 64-year-old Caucasian man previously treated with radiosurgery and brain metastasectomy followed by right middle lobectomy for a squamous cell lung carcinoma had a metachronous solitary metastasis to the thyroid gland, as confirmed by fine-needle aspiration cytology and open biopsy. He underwent curative radiotherapy, with an initial response. At 9 months’ follow-up the tumor relapsed both in the thyroid and the lung.
Review of the literature confirmed that thyroid metastasis from lung cancer is very uncommon in clinical practice. No data on the role of surgery or curative radiotherapy in thyroid metastasis are available because of the lack of prospective studies addressing the impact on survival of these treatment strategies either alone or in combination. In the case described here, radical treatment with radiotherapy allowed to obtain a modest benefit in terms of relapse-free survival. A diagnosis of metastasis to the thyroid gland should be suspected in patients who present a thyroid nodule or suggestive imaging findings when there is a history of malignancy, including lung cancer. Indeed, an early diagnosis allows to pursue radical treatment that, in selected patients, could lead to long-term survival.
Post author correction
Article Type: CASE REPORT
AuthorsFrancesco Gelsomino, Giuseppe Lamberti, Valentina Ambrosini, Francesca Sperandi, Roberto Agosti, Alessio G. Morganti, Andrea Ardizzoni
- • Accepted on 02/01/2017
- • Available online on 23/01/2017
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- Gelsomino, Francesco [PubMed] [Google Scholar] 1, * Corresponding Author (email@example.com)
- Lamberti, Giuseppe [PubMed] [Google Scholar] 2
- Ambrosini, Valentina [PubMed] [Google Scholar] 3
- Sperandi, Francesca [PubMed] [Google Scholar] 1
- Agosti, Roberto [PubMed] [Google Scholar] 4
- Morganti, Alessio G. [PubMed] [Google Scholar] 5
- Ardizzoni, Andrea [PubMed] [Google Scholar] 1
Medical Oncology Unit, Policlinico S. Orsola-Malpighi, Bologna - Italy
Medical Oncology Department, Policlinico S. Orsola-Malpighi, University of Bologna, Bologna - Italy
Nuclear Medicine Unit, Policlinico S. Orsola-Malpighi, University of Bologna, Bologna - Italy
Pathology Section, Policlinico S. Orsola-Malpighi, Bologna - Italy
Radiotherapy Unit, Policlinico S. Orsola-Malpighi, University of Bologna, Bologna - Italy